Yang Binmiao, Zhai Xuejie, Feng Shubo, Hu Dongyan, Deng Yuhua, Shao Zhihui
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
Org Lett. 2019 Jan 4;21(1):330-334. doi: 10.1021/acs.orglett.8b03934. Epub 2018 Dec 26.
The first highly stereoselective intermolecular catalytic asymmetric dearomatization (CADA) of α-naphthols through C-C formation and the first asymmetric allylic dearomatization of naphthols by chiral organocatalysis have been achieved. These new and complete atom-economic reactions provide enantioriched α- and β-naphthalenones bearing an all-carbon quaternary center.
通过碳-碳键形成实现了首例α-萘酚的高度立体选择性分子间催化不对称去芳构化（CADA），并通过手性有机催化实现了首例萘酚的不对称烯丙基去芳构化。这些全新的、完全原子经济性的反应提供了带有全碳季碳中心的对映体富集的α-和β-萘醌。
