缺血性脑水肿的新型成像标志物及其与神经功能结局的关联
Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome.
作者信息
Kimberly W Taylor, Battey Thomas W K, Wu Ona, Singhal Aneesh B, Campbell Bruce C V, Davis Stephen M, Donnan Geoffrey A, Sheth Kevin N
机构信息
Department of Neurology, Massachusetts General Hospital, Lunder 644, 55 Fruit Street, Boston, MA, 02114, USA.
Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
出版信息
Acta Neurochir Suppl. 2016;121:223-6. doi: 10.1007/978-3-319-18497-5_40.
Ischemic cerebral edema (ICE) is a recognized cause of secondary neurological deterioration after large hemispheric stroke, but little is known about the scope of its impact. To study edema in less severe stroke, our group has developed several markers of cerebral edema using brain magnetic resonance imaging (MRI). These tools, which are based on categorical and volumetric measurements in serial diffusion-weighted imaging (DWI), are applicable to a wide variety of stroke volumes. Further, these metrics provide distinct volumetric measurements attributable to ICE, infarct growth, and hemorrhagic transformation. We previously reported that ICE independently predicted neurological outcome after adjustment for known risk factors. We found that an ICE volume of 11 mL or greater was associated with worse neurological outcome.
缺血性脑水肿（ICE）是大面积半球性卒中后继发性神经功能恶化的一个公认原因，但对其影响范围知之甚少。为了研究症状较轻的卒中中的水肿情况，我们团队利用脑磁共振成像（MRI）开发了几种脑水肿标志物。这些工具基于连续扩散加权成像（DWI）中的分类和体积测量，适用于各种卒中体积。此外，这些指标提供了可归因于ICE、梗死灶扩大和出血性转化的不同体积测量值。我们之前报告称，在对已知风险因素进行调整后，ICE可独立预测神经功能预后。我们发现，ICE体积达到或超过11 mL与较差的神经功能预后相关。
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