• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Increasing antibiotic production yields by favoring the biosynthesis of precursor metabolites glucose-1-phosphate and/or malonyl-CoA in Streptomyces producer strains.

作者信息

Zabala Daniel, Braña Alfredo F, Salas José A, Méndez Carmen

机构信息

Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, Oviedo, Spain.

出版信息

J Antibiot (Tokyo). 2016 Mar;69(3):179-82. doi: 10.1038/ja.2015.104. Epub 2015 Oct 14.

DOI:10.1038/ja.2015.104
PMID:26464013
Abstract
摘要

相似文献

1
Increasing antibiotic production yields by favoring the biosynthesis of precursor metabolites glucose-1-phosphate and/or malonyl-CoA in Streptomyces producer strains.通过促进链霉菌生产菌株中前体代谢物葡萄糖-1-磷酸和/或丙二酰辅酶A的生物合成来提高抗生素产量。
J Antibiot (Tokyo). 2016 Mar;69(3):179-82. doi: 10.1038/ja.2015.104. Epub 2015 Oct 14.
2
Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus.工程前体代谢物池以增加抗肿瘤密曲霉素在灰链霉菌中的产量。
Metab Eng. 2013 Nov;20:187-97. doi: 10.1016/j.ymben.2013.10.002. Epub 2013 Oct 19.
3
Metabolic engineering of Nocardia sp. CS682 for enhanced production of nargenicin A₁.通过代谢工程改造诺卡氏菌 CS682 以提高那格列汀 A₁ 的产量。
Appl Biochem Biotechnol. 2012 Feb;166(3):805-17. doi: 10.1007/s12010-011-9470-1. Epub 2011 Dec 9.
4
[Precursor formation and biosynthesis of the macrolide antibiotic a 6599 (turimycin) by streptomyces hygroscopicus JA 6599].
Z Allg Mikrobiol. 1975;15(4):249-57. doi: 10.1002/jobm.3630150405.
5
Negative feedback regulation of fatty acid production based on a malonyl-CoA sensor-actuator.基于丙二酰辅酶A传感器-执行器的脂肪酸生成负反馈调节。
ACS Synth Biol. 2015 Feb 20;4(2):132-40. doi: 10.1021/sb400158w. Epub 2014 Jan 10.
6
Improving fatty acid production in Escherichia coli through the overexpression of malonyl coA-acyl carrier protein transacylase.通过过表达丙二酰辅酶 A-酰基载体蛋白转酰基酶提高大肠杆菌中的脂肪酸产量。
Biotechnol Prog. 2012 Jan-Feb;28(1):60-5. doi: 10.1002/btpr.716. Epub 2011 Oct 28.
7
Improvement of Rimocidin Biosynthesis by Increasing Supply of Precursor Malonyl-CoA via Over-expression of Acetyl-CoA Carboxylase in Streptomyces rimosus M527.通过在里氏木霉 M527 中过表达乙酰辅酶 A 羧化酶来增加前体丙二酰辅酶 A 的供应,从而提高里莫西菌素的生物合成。
Curr Microbiol. 2022 Apr 30;79(6):174. doi: 10.1007/s00284-022-02867-9.
8
Overexpression of acetyl-CoA carboxylase in Aspergillus terreus to increase lovastatin production.在土曲霉中过表达乙酰辅酶 A 羧化酶以提高洛伐他汀的产量。
N Biotechnol. 2018 Sep 25;44:64-71. doi: 10.1016/j.nbt.2018.04.008. Epub 2018 May 1.
9
Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis with metabolic engineering.通过传统诱变与代谢工程相结合提高吸水链霉菌中 FK520 的产量。
Appl Microbiol Biotechnol. 2019 Dec;103(23-24):9593-9606. doi: 10.1007/s00253-019-10192-8. Epub 2019 Nov 12.
10
Identification and characterization of acetyl-CoA carboxylase gene cluster in Streptomyces toxytricini.毒三素链霉菌中乙酰辅酶A羧化酶基因簇的鉴定与表征
J Microbiol. 2009 Aug;47(4):473-8. doi: 10.1007/s12275-009-0135-5. Epub 2009 Sep 9.

引用本文的文献

1
Engineering the TCA cycle regulator GarA to increase erythromycin production in .改造三羧酸循环调节因子GarA以提高红霉素产量 。 (原文句末“in.”似乎不完整,推测可能是在某个特定物种中,这里按照现有内容准确翻译)
Microbiology (Reading). 2025 Aug;171(8). doi: 10.1099/mic.0.001583.
2
Regulatory orchestration of FK506 biosynthesis in NRRL 18488 revealed through systematic analysis.通过系统分析揭示NRRL 18488中FK506生物合成的调控编排
iScience. 2025 May 19;28(6):112698. doi: 10.1016/j.isci.2025.112698. eCollection 2025 Jun 20.
3
Proteomic examination of polyester-polyurethane degradation by Streptomyces sp. PU10: Diverting polyurethane intermediates to secondary metabolite production.

本文引用的文献

1
Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus.工程前体代谢物池以增加抗肿瘤密曲霉素在灰链霉菌中的产量。
Metab Eng. 2013 Nov;20:187-97. doi: 10.1016/j.ymben.2013.10.002. Epub 2013 Oct 19.
2
Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.噬菌体 p1 衍生的人工染色体促进 FK506 基因簇的异源表达。
PLoS One. 2013 Jul 11;8(7):e69319. doi: 10.1371/journal.pone.0069319. Print 2013.
3
Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring.
链霉菌属PU10对聚酯型聚氨酯降解的蛋白质组学研究:将聚氨酯中间体转化为次级代谢产物的生成
Microb Biotechnol. 2024 Mar;17(3):e14445. doi: 10.1111/1751-7915.14445.
4
Rethinking Biosynthesis of Aclacinomycin A.重新思考阿克拉霉素 A 的生物合成。
Molecules. 2023 Mar 18;28(6):2761. doi: 10.3390/molecules28062761.
5
Multi-strategy engineering unusual sugar TDP-l-mycarose biosynthesis to improve the production of 3---mycarosylerythronolide B in .多策略工程改造异常糖TDP-L-鼠李糖生物合成以提高在……中3-O-鼠李糖基红霉内酯B的产量。
Synth Syst Biotechnol. 2022 Mar 20;7(2):756-764. doi: 10.1016/j.synbio.2022.03.002. eCollection 2022 Jun.
6
A BioBricks toolbox for metabolic engineering of the tetracenomycin pathway.四环霉素途径代谢工程的生物积木工具箱。
Biotechnol J. 2022 Mar;17(3):e2100371. doi: 10.1002/biot.202100371. Epub 2021 Nov 12.
7
Pathway Engineering of Anthracyclines: Blazing Trails in Natural Product Glycodiversification.蒽环类药物的途径工程:天然产物糖基多样化的开拓之路。
J Org Chem. 2020 Oct 2;85(19):12012-12023. doi: 10.1021/acs.joc.0c01863. Epub 2020 Sep 22.
8
Engineering microbial hosts for production of bacterial natural products.工程化微生物宿主用于生产细菌天然产物。
Nat Prod Rep. 2016 Aug 27;33(8):963-87. doi: 10.1039/c6np00017g. Epub 2016 Apr 13.
阐明聚酮-非核糖体肽类抗生素科利霉素A的生物合成途径:2,2'-联吡啶环的形成机制。
Chem Biol. 2012 Mar 23;19(3):399-413. doi: 10.1016/j.chembiol.2012.01.014.
4
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.链霉菌产生 RNA 聚合酶抑制剂链道霉素的生物合成中氨基酸前体的供应。
J Bacteriol. 2011 Aug;193(16):4214-23. doi: 10.1128/JB.05062-11. Epub 2011 Jun 10.
5
The regulation of the secondary metabolism of Streptomyces: new links and experimental advances.链霉菌次级代谢的调控:新的关联和实验进展。
Nat Prod Rep. 2011 Jul;28(7):1311-33. doi: 10.1039/c1np00003a. Epub 2011 May 25.
6
The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042.肉桂链霉菌 DSM 1042 中,二萜化苯并嗪的生物合成基因位于两个不同的染色体位置上。
Microb Biotechnol. 2011 Mar;4(2):252-62. doi: 10.1111/j.1751-7915.2010.00234.x. Epub 2010 Dec 8.
7
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.工程化变铅青链霉菌用于异源表达次级代谢产物基因簇。
Microb Biotechnol. 2011 Mar;4(2):207-15. doi: 10.1111/j.1751-7915.2010.00219.x. Epub 2010 Oct 26.
8
High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.在肉桂色链霉菌工业莫能菌素生产菌株中通过异源表达途径生产四烯霉素的高滴度。
Metab Eng. 2009 Nov;11(6):319-27. doi: 10.1016/j.ymben.2009.06.004. Epub 2009 Jul 10.
9
Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.对RNA聚合酶或核糖体蛋白S12发生突变的放线菌菌株进行抗菌研究。
Nat Biotechnol. 2009 May;27(5):462-4. doi: 10.1038/nbt.1538. Epub 2009 Apr 26.
10
Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.通过组合生物合成改变糖基化模式来生成抗肿瘤抗生素光神霉素的新衍生物。
Chembiochem. 2008 Sep 22;9(14):2295-304. doi: 10.1002/cbic.200800299.