Epidemiology Group, Institute of Applied Health Sciences, University of Aberdeen, UK.
Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK.
Eur J Prev Cardiol. 2016 Jun;23(9):938-46. doi: 10.1177/2047487315610663. Epub 2015 Oct 13.
To examine for a possible relationship between osteoarthritis and cardiovascular disease.
A systematic review and meta-analysis.
Published and unpublished literature from: MEDLINE, EMBASE, CINAHL, the Cochrane Library, OpenGrey and clinical trial registers. Search to 22 November 2014. Cohort, case-control, randomised and non-randomised controlled trial papers reporting the prevalence of cardiovascular disease in osteoarthritis were included.
Fifteen studies with 32,278,744 individuals were eligible. Pooled prevalence for overall cardiovascular disease pathology in people with osteoarthritis was 38.4% (95% confidence interval (CI): 37.2% to 39.6%). Individuals with osteoarthritis were almost three times as likely to have heart failure (relative risk (RR): 2.80; 95% CI: 2.25 to 3.49) or ischaemic heart disease (RR: 1.78; 95% CI: 1.18 to 2.69) compared with matched non-osteoarthritis cohorts. No significant difference was detected between the two groups for the risk of experiencing myocardial infarction or stroke. There was a three-fold decrease in the risk of experiencing a transient ischaemic attack in the osteoarthritis cohort compared with the non-osteoarthritis group.
Prevalence of cardiovascular disease in patients with osteoarthritis is significant. There was an observed increased risk of incident heart failure and ischaemic heart disease in people with osteoarthritis compared with matched controls. However, the relationship between osteoarthritis and cardiovascular disease is not straightforward and there is a need to better understand the potential common pathways linking pathophysiological mechanisms.
研究骨关节炎与心血管疾病之间可能存在的关系。
系统评价和荟萃分析。
检索 MEDLINE、EMBASE、CINAHL、Cochrane 图书馆、OpenGrey 和临床试验注册数据库，查找截至 2014 年 11 月 22 日发表和未发表的文献。纳入报告骨关节炎患者心血管疾病患病率的队列研究、病例对照研究、随机对照试验和非随机对照试验文献。
15 项研究共纳入 32278744 例患者。骨关节炎患者总体心血管疾病患病率为 38.4%（95%可信区间：37.2%至 39.6%）。与匹配的非骨关节炎队列相比，骨关节炎患者发生心力衰竭（相对风险：2.80；95%可信区间：2.25 至 3.49）或缺血性心脏病（相对风险：1.78；95%可信区间：1.18 至 2.69）的风险几乎增加了两倍。两组发生心肌梗死或卒中的风险无显著差异。与非骨关节炎组相比，骨关节炎组发生短暂性脑缺血发作的风险降低了三分之一。
骨关节炎患者心血管疾病的患病率显著增加。与匹配对照相比，骨关节炎患者新发心力衰竭和缺血性心脏病的风险增加。然而，骨关节炎与心血管疾病之间的关系并不简单，需要更好地了解将病理生理机制联系起来的潜在共同途径。
