Rezvani Gita, Donoghue Mandana, Reichart Peter A, Pazuhi Neda
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shahed University, Tehran, Iran.
OMFP Center, Belgaum, India.
Open Dent J. 2015 Jul 31;9:340-5. doi: 10.2174/1874210601509010340. eCollection 2015.
A 24 year-old male was presented for the diagnosis of an asymptomatic bony expansion in relation to the right maxillary canine and first premolar. The unilocular radiolucent lesion with central foci of calcification had caused divergence of canine and first premolar roots without any resorption. This case report details a diagnosis of two distinct disease processes of different cellular origin namely, focal cemento-ossifying dysplasia and adenomatoid odontogenic tumor in a previously unreported concomitant and contiguous relationship. The diagnosis was determined by a combination of clinical, radiographic, histopathological and surgical evidence. This case highlights two points, first the need to examine all mixed radiolucent-radiopaque lesions with advanced imaging techniques to assess the number and extent of the lesions prior to treatment planning. Second a likely role of periodontal ligament as the tissue source for odontogenic epithelial cells and mesenchymal stem cells required for the development of odontogenic tumors and cemento-osseous dysplasias.
一名24岁男性因右侧上颌尖牙和第一前磨牙处无症状性骨质膨胀前来诊断。具有中央钙化灶的单房性透射性病变导致尖牙和第一前磨牙牙根分开，且无任何吸收。本病例报告详细描述了两种不同细胞起源的独特疾病过程，即局灶性牙骨质骨化发育异常和腺样牙源性肿瘤，它们以前未被报道过以伴随且相邻的关系出现。诊断是通过临床、影像学、组织病理学和手术证据相结合来确定的。本病例突出了两点，第一，在治疗计划前，需要用先进的成像技术检查所有混合性透射性-阻射性病变，以评估病变的数量和范围。第二，牙周膜可能作为牙源性上皮细胞和间充质干细胞的组织来源，这些细胞是牙源性肿瘤和牙骨质骨发育异常发生所必需的。
