Li Jingjing, Gao Beibei, Huang Zufa, Duan Tong, Li Daiqiang, Zhang Sheng, Zhao Yujun, Liu Lian, Wang Qiang, Chen Zhizhao, Cheng Ke
Department of Pathology, Xiangya Basic Medical College, Central South University Changsha 410013, China.
Department of Pathology, The Second Xiangya Hospital of Central South University Changsha 410013, China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9512-6. eCollection 2015.
MircroRNA functions as a tumor suppressor or a promoter in cholangiocarcinoma (CCA). Researchers have found that miR-203 functioned as tumor suppressor in many types of cancer. However, the role of miR-203 that plays in CCA remains to be clarified. We aimed to detect the expression level and the prognostic significance of miR-203 in CCA tissues. qRT-RCR was performed to examine the miR-203 expression levels in CCA tissue specimens and corresponding normal tissues. Our findings suggest that miR-203 expression was an independent poor prognostic factor for CCA patient overall survival. Therefore, miR-203 may serve as a valuable prognostic marker and promising treatment target for CCA.
微小RNA在胆管癌（CCA）中起着肿瘤抑制因子或促进因子的作用。研究人员发现，miR-203在多种癌症中发挥肿瘤抑制作用。然而，miR-203在CCA中所起的作用仍有待阐明。我们旨在检测miR-203在CCA组织中的表达水平及其预后意义。采用qRT-RCR检测CCA组织标本及相应正常组织中miR-203的表达水平。我们的研究结果表明，miR-203表达是CCA患者总生存的独立不良预后因素。因此，miR-203可能作为CCA的一个有价值的预后标志物和有前景的治疗靶点。
