Department of Medicine; Division of General Internal Medicine , University of Colorado (CU) School of Medicine (SOM) , Aurora, Colorado , USA ; Center for Women's Health Research , Aurora, Colorado , USA.
Center for Women's Health Research , Aurora, Colorado , USA ; Division of Geriatrics, Aurora, Colorado , USA.
BMJ Open Diabetes Res Care. 2015 Sep 30;3(1):e000124. doi: 10.1136/bmjdrc-2015-000124. eCollection 2015.
Type 2 diabetes mellitus (T2DM) is associated with high levels of disability and mortality. Regular exercise prevents premature disability and mortality, but people with T2DM are generally sedentary for reasons that are not fully established. We previously observed that premenopausal women with T2DM report greater effort during exercise than their counterparts without diabetes, as measured by the Rating of Perceived Exertion (RPE) scale. We hypothesized that RPE is greater in older women with T2DM versus no T2DM.
We enrolled overweight, sedentary women aged 50-75 years with (n=26) or without T2DM (n=28). Participants performed submaximal cycle ergometer exercise at 30 W and 35% of individually-measured peak oxygen consumption (35% VO2peak). We assessed exercise effort by RPE (self-report) and plasma lactate concentration.
VO2peak was lower in T2DM versus controls (p=0.003). RPE was not significantly greater in T2DM versus controls (30 W: Control, 10.4±3.2, T2DM, 11.7±2.3, p=0.08; 35% VO2peak: Control, 11.1±0.5, T2DM, 12.1±0.5, p=0.21). However, lactate was greater in T2DM versus controls (p=0.004 at 30 W; p<0.05 at 35% VO2peak). Greater RPE was associated with higher lactate, higher heart rate, and a hypertension diagnosis (p<0.05 at 30 W and 35% VO2peak).
Taken together, physiological measures of exercise effort were greater in older women with T2DM than controls. Exercise effort is a modifiable and thereby targetable end point. In order to facilitate regular exercise, methods to reduce exercise effort in T2DM should be sought.
NCT00785005.
2 型糖尿病（T2DM）与高残疾率和高死亡率相关。有规律的运动可以预防过早残疾和死亡，但由于某些原因，T2DM 患者通常久坐不动，这些原因尚未完全确定。我们之前观察到，患有 T2DM 的绝经前女性在运动时比没有糖尿病的女性报告说感觉更吃力，这是通过感知用力程度（RPE）量表来衡量的。我们假设，与无 T2DM 相比，老年 T2DM 女性的 RPE 更高。
我们招募了年龄在 50-75 岁之间、超重且久坐不动的女性，其中患有 T2DM（n=26）或无 T2DM（n=28）。参与者在 30W 和 35%个体测量峰值摄氧量（35% VO2peak）下进行次最大自行车测力计运动。我们通过 RPE（自我报告）和血浆乳酸浓度来评估运动用力程度。
T2DM 患者的 VO2peak 低于对照组（p=0.003）。T2DM 患者的 RPE 与对照组相比并没有显著更高（30W：对照组 10.4±3.2，T2DM 组 11.7±2.3，p=0.08；35% VO2peak：对照组 11.1±0.5，T2DM 组 12.1±0.5，p=0.21）。然而，T2DM 患者的乳酸水平高于对照组（p=0.004 在 30W；p<0.05 在 35% VO2peak）。更大的 RPE 与更高的乳酸水平、更高的心率和高血压诊断相关（p<0.05 在 30W 和 35% VO2peak）。
总的来说，与对照组相比，老年 T2DM 女性的运动用力生理指标更高。运动用力是一个可调节的、可靶向的终点。为了促进有规律的运动，应该寻求减少 T2DM 运动用力的方法。
NCT00785005。
