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电针治疗非行走性椎间盘疾病犬脑脊液中S100β水平

S100β Levels in CSF of Nonambulatory Dogs with Intervertebral Disk Disease Treated with Electroacupuncture.

作者信息

Murata Hayashi Ayne, Fonseca Pinto Ana Carolina Brandão Campos, Cortopassi Silvia Renata Gaido, Marvulle Valdecir, Ruivo Maximino Jessica, Chadi Gerson, Matera Julia Maria

机构信息

Department of Surgery, School of Veterinary Medicine and Animal Science, The University of São Paulo, 05508-270 São Paulo, SP, Brazil.

Center of Mathematics, Computation and Cognition, The Federal University of ABC, 09210-170 Santo André, SA, Brazil.

出版信息

J Vet Med. 2013;2013:549058. doi: 10.1155/2013/549058. Epub 2013 Dec 29.

DOI:10.1155/2013/549058
PMID:26464906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4590852/
Abstract

The aim of the study was to investigate S100β levels in the cerebrospinal fluid of nonambulatory dogs with intervertebral disk disease treated with electroacupuncture: 10 dogs with thoracolumbar disk extrusion graded 3 to 5 (EA group) and 7 dogs without neurologic dysfunction (control group). All dogs regained ambulation. S100β was detected by Western blot analysis where EA group dogs were evaluated at two time points (M1 = before EA and M2 = when the dogs return ambulation) and at one time point from control group. In EA group dogs M1-S100β levels were significantly higher than in control group. EA group dogs were divided into subgroups A (n = 7-early motor recovery; 6.7 ± 7.8 days) and B (n = 3-late motor recovery; 76 ± 17.0 days). M1-S100β levels were similar between subgroups A and B. However, M2-S100β levels were significantly higher in subgroup B than in subgroup A. An elevated S100β levels were observed in dogs with late motor recovery. S100β may be associated with neuroplasticity following spinal cord injuries with intervertebral disk extrusion. Further studies with larger numbers of subjects and control group with affected dogs are necessary to investigate the relationship between neurotrophic factors and electroacupuncture stimulation.

摘要

本研究的目的是调查接受电针治疗的非行走性椎间盘疾病犬脑脊液中的S100β水平：10只胸腰椎间盘突出症分级为3至5级的犬（电针组）和7只无神经功能障碍的犬（对照组）。所有犬均恢复了行走能力。通过蛋白质印迹分析检测S100β，电针组犬在两个时间点（M1 = 电针治疗前，M2 = 犬恢复行走时）进行评估，对照组在一个时间点进行评估。电针组犬的M1-S100β水平显著高于对照组。电针组犬分为A亚组（n = 7，运动恢复早；6.7±7.8天）和B亚组（n = 3，运动恢复晚；76±17.0天）。A亚组和B亚组之间的M1-S100β水平相似。然而，B亚组的M2-S100β水平显著高于A亚组。运动恢复晚的犬中观察到S100β水平升高。S100β可能与椎间盘突出脊髓损伤后的神经可塑性有关。需要更多受试者和患犬对照组进行进一步研究，以探讨神经营养因子与电针刺激之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/4590852/50680a11bcb0/JVM2013-549058.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/4590852/09a824ec0b81/JVM2013-549058.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/4590852/50680a11bcb0/JVM2013-549058.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/4590852/09a824ec0b81/JVM2013-549058.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/4590852/50680a11bcb0/JVM2013-549058.002.jpg

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