Celestine Okwudili Ukwueze, Athanasius Chinedu Eze, Jonas Anayo Ona
Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Abia State, Nigeria.
Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
J Vet Med. 2014;2014:758581. doi: 10.1155/2014/758581. Epub 2014 Sep 11.
Anaesthesia was induced in West African Dwarf (WAD) goats using different combinations of propofol (P), xylazine (X), and ketamine (K), and the biochemical effect of the drugs determined. Twenty male (WAD) goats were randomly assigned to five treatment groups viz. Control (C) (2.5 mL IV normal saline); group K + X (5 mg/kg IV ketamine + 0.05 mg/kg IV xylazine), group P + X (5 mg/kg IV propofol + 0.05 mg/kg IV xylazine), group P + K (propofol 5 mg/kg IV + ketamine 5 mg/kg IV), and group P + K + X (propofol 2.5 mg/kg IV + ketamine 2.5 mg/kg IV + xylazine 0.05 mg/kg IV), respectively. There was increase (P < 0.05) in blood glucose in K + X, P + X and P + K + X. The serum cortisol level increased (P < 0.05) in all groups except in P + X. ALT value increased (P < 0.05) in K + X, P + K, and P + K + X. BUN increased (P < 0.05) in K + X but decreased (P < 0.05) in P + K + X. There was no significant variation (P > 0.05) in serum creatinine. These biochemical changes were transient. P + K + X would be the best drug combinations considering the biochemical parameter measured. However, data on blood glucose, ALT, BUN, and cortisol levels in an anaesthsized goat should be interpreted with caution in order to avoid erroneous interpretation in these animals.
使用丙泊酚（P）、赛拉嗪（X）和氯胺酮（K）的不同组合对西非矮山羊（WAD）进行麻醉，并测定药物的生化效应。将20只雄性（WAD）山羊随机分为五个治疗组，即对照组（C）（静脉注射2.5 mL生理盐水）；K + X组（静脉注射5 mg/kg氯胺酮 + 0.05 mg/kg赛拉嗪），P + X组（静脉注射5 mg/kg丙泊酚 + 0.05 mg/kg赛拉嗪），P + K组（静脉注射5 mg/kg丙泊酚 + 5 mg/kg氯胺酮），以及P + K + X组（静脉注射2.5 mg/kg丙泊酚 + 2.5 mg/kg氯胺酮 + 0.05 mg/kg赛拉嗪）。K + X组、P + X组和P + K + X组的血糖升高（P < 0.05）。除P + X组外，所有组的血清皮质醇水平均升高（P < 0.05）。K + X组、P + K组和P + K + X组的谷丙转氨酶（ALT）值升高（P < 0.05）。K + X组的血尿素氮（BUN）升高（P < 0.05），而P + K + X组的BUN降低（P < 0.05）。血清肌酐无显著变化（P > 0.05）。这些生化变化是短暂的。考虑到所测量的生化参数，P + K + X将是最佳的药物组合。然而，对于麻醉山羊的血糖、ALT、BUN和皮质醇水平数据，应谨慎解释，以避免对这些动物的错误解读。
