Celestine Okwudili Ukwueze, Chinedu Athanasius Eze, Rita Ijeoma Udegbunam
Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, Michael Okpara University of Agriculture, PMB 7267, Umudike, Umuahia, Abia State, Nigeria.
Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
J Vet Med. 2014;2014:962560. doi: 10.1155/2014/962560. Epub 2014 Oct 16.
The assessment of anaesthetic and clinical indices of multimodal therapy of propofol, xylazine, and ketamine was done in West African Dwarf (WAD) goat. Sixteen healthy male WAD goats were assigned into four treatment groups, namely, control (group A) (ketamine 5 mg/kg + xylazine 0.05 mg/kg), group B (propofol 5 mg/kg + xylazine 0.05 mg/kg), group C (propofol 5 mg/kg + ketamine 5 mg/kg), and group D (propofol 2.5 mg/kg + ketamine 2.5 mg/kg + xylazine 0.05 mg/kg). All drugs were administered intravenously. The multimodal therapy decreased significantly (P < 0.05) the heart rate in groups A, B, and D. Also respiratory rate significantly (P < 0.05) decreased in groups A, B, and D but significantly (P < 0.05) increased at 20 min after induction in group C. However, temperature significantly (P < 0.05) decreased in groups A, B, and C. The induction was good and smooth in groups B and D. Surgical anaesthetic time was longer in groups B and D and shorter in group C. The quality of recovery was good in groups B and D. Side effects such as salivation and apnoea were observed in all groups. In conclusion, the multimodal therapy could be used successfully. However, group D could be the best combination considering the parameters measured.
在西非矮山羊中对丙泊酚、赛拉嗪和氯胺酮多模式疗法的麻醉和临床指标进行了评估。16只健康的雄性西非矮山羊被分为四个治疗组，即对照组（A组）（氯胺酮5mg/kg + 赛拉嗪0.05mg/kg）、B组（丙泊酚5mg/kg + 赛拉嗪0.05mg/kg）、C组（丙泊酚5mg/kg + 氯胺酮5mg/kg）和D组（丙泊酚2.5mg/kg + 氯胺酮2.5mg/kg + 赛拉嗪0.05mg/kg）。所有药物均通过静脉注射给药。多模式疗法使A组、B组和D组的心率显著降低（P < 0.05）。A组、B组和D组的呼吸频率也显著降低（P < 0.05），但C组在诱导后20分钟时显著升高（P < 0.05）。然而，A组、B组和C组的体温显著降低（P < 0.05）。B组和D组的诱导良好且平稳。B组和D组的手术麻醉时间较长，C组较短。B组和D组的恢复质量良好。所有组均观察到流涎和呼吸暂停等副作用。总之，多模式疗法可以成功应用。然而，考虑到所测量的参数，D组可能是最佳组合。
