Gomperts Stephen N, Kloosterman Fabian, Wilson Matthew A
Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, United States.
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.
Elife. 2015 Oct 14;4:e05360. doi: 10.7554/eLife.05360.
Spatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role. To test whether the coordination of VTA reward prediction error signals with these replayed spatial sequences could contribute to this process, we recorded from neuronal ensembles of the hippocampus and VTA as rats performed appetitive spatial tasks and subsequently slept. We found that many reward responsive (RR) VTA neurons coordinated with quiet wakefulness-associated hippocampal SPW-R events that replayed recent experience. In contrast, coordination between RR neurons and SPW-R events in subsequent slow wave sleep was diminished. Together, these results indicate distinct contributions of VTA reinforcement activity associated with hippocampal spatial replay to the processing of wake and SWS-associated spatial memory.
空间学习需要海马体，并且在安静觉醒和睡眠期间海马体尖波-涟漪（SPW-R）事件中空间序列的重放被认为起着关键作用。为了测试腹侧被盖区（VTA）奖励预测误差信号与这些重放的空间序列的协调是否有助于这一过程，我们在大鼠执行奖赏性空间任务并随后睡眠时，记录了海马体和VTA的神经元集群活动。我们发现，许多奖励反应性（RR）VTA神经元与重放近期经历的安静觉醒相关海马体SPW-R事件相协调。相比之下，RR神经元与随后慢波睡眠中的SPW-R事件之间的协调性减弱。总之，这些结果表明，与海马体空间重放相关的VTA强化活动对觉醒和慢波睡眠相关空间记忆的处理有不同贡献。
