Nielsen Louise A, Bøjsøe Christine, Kloppenborg Julie T, Trier Cæcilie, Gamborg Michael, Holm Jens-Christian
The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, DK 4300, Holbæk, Denmark.
The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, DK 4300, Holbæk, Denmark; Department of Paediatrics, Copenhagen University Hospital Herlev, DK 2730, Herlev, Denmark.
PLoS One. 2015 Mar 10;10(3):e0120177. doi: 10.1371/journal.pone.0120177. eCollection 2015.
The aim was to investigate whether a familial predisposition to obesity related cardiovascular complications was associated with the degree of obesity at baseline and/or changes in the degree of obesity during a multidisciplinary childhood obesity treatment program.
The study included 1421 obese children (634 boys) with a median age of 11.5 years (range 3.1-17.9 years), enrolled in treatment for 0.04 to 5.90 years (median 1.3 years) at the Children's Obesity Clinic, Denmark. At baseline, weight and height were measured, body mass index (BMI) standard deviation score (SDS) calculated, and self-reported information on familial predisposition to obesity, hypertension, type 2 diabetes mellitus (T2DM), thromboembolic events, and dyslipidaemia were obtained. A familial predisposition included events in biological parents, siblings, grandparents, uncles, and aunts. The treatment outcomes were categorically analysed according to the prevalence of familial predispositions.
The median BMI SDS at enrollment was 3.2 in boys and 2.8 in girls. One-thousand-and-forty-one children had obesity in their family, 773 had hypertension, 551 had T2DM, 568 had thromboembolic events, and 583 had dyslipidaemia. Altogether, 733 had three or more predispositions. At baseline, familial T2DM was associated with a higher mean BMI SDS (p = 0.03), but no associations were found between the other predispositions and the children's degree of obesity. During treatment, girls with familial obesity lost more weight, compared to girls without familial obesity (p = 0.04). No other familial predispositions were associated with changes in BMI SDS during treatment.
Obese children with a familial predisposition to T2DM showed a significantly higher degree of obesity at baseline and girls with familial obesity responded better to treatment. Besides these findings, no other associations were found between the occurrence of familial predispositions and the degree of obesity or changes herein during multidisciplinary childhood obesity treatment.
本研究旨在调查肥胖相关心血管并发症的家族易感性是否与基线时的肥胖程度和/或多学科儿童肥胖治疗项目期间肥胖程度的变化相关。
该研究纳入了1421名肥胖儿童（634名男孩），中位年龄为11.5岁（范围3.1 - 17.9岁），在丹麦儿童肥胖诊所接受了0.04至5.90年（中位1.3年）的治疗。在基线时，测量体重和身高，计算体重指数（BMI）标准差评分（SDS），并获取关于肥胖、高血压、2型糖尿病（T2DM）、血栓栓塞事件和血脂异常家族易感性的自我报告信息。家族易感性包括亲生父母、兄弟姐妹、祖父母、叔叔和阿姨中的相关事件。根据家族易感性的患病率对治疗结果进行分类分析。
入组时男孩的中位BMI SDS为3.2，女孩为2.8。1041名儿童有家族肥胖，773名有高血压，551名有T2DM，568名有血栓栓塞事件，583名有血脂异常。共有733名儿童有三种或更多易感性。在基线时，家族性T2DM与较高的平均BMI SDS相关（p = 0.03），但其他易感性与儿童肥胖程度之间未发现关联。在治疗期间，有家族肥胖的女孩比没有家族肥胖的女孩减重更多（p = 0.04）。治疗期间没有其他家族易感性与BMI SDS的变化相关。
有T2DM家族易感性的肥胖儿童在基线时肥胖程度显著更高，有家族肥胖的女孩对治疗反应更好。除了这些发现外，在多学科儿童肥胖治疗期间，家族易感性的发生与肥胖程度或其变化之间未发现其他关联。
