Guillaume M, Lapidus L, Beckers F, Lambert A, Björntorp P
Division of Pediatrics, Cliniques Universitaires St Luc, Brussels, Belgium.
Int J Obes Relat Metab Disord. 1995 Sep;19 Suppl 3:S5-9.
Province de Luxembourg in Belgium is an area with clustering of obesity as well as other risk factors for cardiovascular diseases and non-insulin dependent diabetes mellitus. In this study, obesity was studied in a total of 1028 boys and girls in age-strata 6-8, 8-10, 10-12 years, selected at random from school classes. Participation rate was about 70%. Non-participants did not differ from participants in comparisons of school records of height and weight. Furthermore, information on birth weight, parents' height and weight was collected, as well as reported problems of obesity in grandparents. The results show a high prevalence of pronounced obesity in these children. BMIs were strongly correlated between the children and both parents. Furthermore, grandparents' obesity problems were related to the BMI of parents, and also to obesity indices in the children. Birth weights were related to current BMI of the children (in girls only for the youngest age-group), and to their mothers' BMI. It was concluded that obesity is prevalent in this area and can be traced through three generations, and seems to be discoverable already at birth. Energy intake is high and physical activity level is low in these children. However, statistical analyses suggest that familial factors exert a greater impact than environmental factors on the BMI of the children. These results, as well as the wide-spread, consistent familial clustering of obesity, traceable already at birth, suggest influence of strong genetic traits for obesity in this population.
比利时的卢森堡省是一个肥胖以及心血管疾病和非胰岛素依赖型糖尿病等其他风险因素聚集的地区。在这项研究中，从6 - 8岁、8 - 10岁、10 - 12岁年龄组的学校班级中随机选取了1028名男孩和女孩进行肥胖研究。参与率约为70%。在身高和体重的学校记录比较中，未参与者与参与者没有差异。此外，收集了出生体重、父母身高和体重的信息，以及祖父母肥胖问题的报告。结果显示这些儿童中明显肥胖的患病率很高。儿童与父母双方的体重指数（BMI）密切相关。此外，祖父母的肥胖问题与父母的BMI有关，也与儿童的肥胖指数有关。出生体重与儿童当前的BMI有关（仅在最年幼年龄组的女孩中如此），也与她们母亲的BMI有关。研究得出结论，肥胖在该地区普遍存在，并且可以追溯三代，似乎在出生时就已显现。这些儿童的能量摄入量高而身体活动水平低。然而，统计分析表明，家族因素对儿童BMI的影响大于环境因素。这些结果，以及肥胖在出生时就已存在的广泛、一致的家族聚集现象，表明该人群中存在强大的肥胖遗传特征影响。
