埃博拉病毒性传播的分子证据
Molecular Evidence of Sexual Transmission of Ebola Virus.
作者信息
Mate Suzanne E, Kugelman Jeffrey R, Nyenswah Tolbert G, Ladner Jason T, Wiley Michael R, Cordier-Lassalle Thierry, Christie Athalia, Schroth Gary P, Gross Stephen M, Davies-Wayne Gloria J, Shinde Shivam A, Murugan Ratnesh, Sieh Sonpon B, Badio Moses, Fakoli Lawrence, Taweh Fahn, de Wit Emmie, van Doremalen Neeltje, Munster Vincent J, Pettitt James, Prieto Karla, Humrighouse Ben W, Ströher Ute, DiClaro Joseph W, Hensley Lisa E, Schoepp Randal J, Safronetz David, Fair Joseph, Kuhn Jens H, Blackley David J, Laney A Scott, Williams Desmond E, Lo Terrence, Gasasira Alex, Nichol Stuart T, Formenty Pierre, Kateh Francis N, De Cock Kevin M, Bolay Fatorma, Sanchez-Lockhart Mariano, Palacios Gustavo
机构信息
From the Center for Genome Sciences (S.E.M., J.R.K., J.T.L., M.R.W., K.P., M.S.-L., G.P.) and Diagnostic Systems Division (R.J.S.), U.S. Army Medical Research Institute of Infectious Diseases, and the Division of Clinical Research, Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) (J.P., L.E.H., J.H.K.) - all in Frederick, MD; the Ministry of Health and Social Welfare (T.G.N., S.B.S., M.B., F.N.K.) and the World Health Organization (WHO) (G.J.D.-W., R.M.), Monrovia, and the Liberian Institute for Biomedical Research, Charlesville (L.F., F.T., F.B.) - all in Liberia; WHO, Geneva (T.C.-L., A.G., P.F.); the Centers for Disease Control and Prevention, Atlanta (A.C., B.W.H., U.S., D.J.B., A.S.L., D.E.W., T.L., S.T.N., K.M.D.C.); Illumina, San Diego, CA (G.P.S., S.M.G.); WHO, New Delhi, India (S.A.S); Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT (E.W., N.D., V.J.M., D.S.); Naval Medical Research Unit 3, Cairo (J.W.D.); and the Foundation Mérieux, Washington, DC (J.F.).
出版信息
N Engl J Med. 2015 Dec 17;373(25):2448-54. doi: 10.1056/NEJMoa1509773. Epub 2015 Oct 14.
A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. (Funded by the Defense Threat Reduction Agency and others.).
2015年3月在利比里亚发生了一起疑似埃博拉病毒病（EVD）男性幸存者将病毒传播给其女性伴侣（本报告中的患者）的病例。从患者血液样本和幸存者精液样本中组装的埃博拉病毒（EBOV）基因组与直接传播一致。这些基因组共有三个替代突变，在所有其他西非EBOV序列中均不存在，且与该病例之前利比里亚最后记录的传播链不同。结合流行病学数据，基因组分析提供了EBOV性传播的证据，以及EVD发病后感染性EBOV在精液中持续存在179天或更长时间的证据。（由国防威胁降低局等资助。）
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