病毒学。来自马里病例序列的埃博拉病毒的突变率和基因型变异
Virology. Mutation rate and genotype variation of Ebola virus from Mali case sequences.
作者信息
Hoenen T, Safronetz D, Groseth A, Wollenberg K R, Koita O A, Diarra B, Fall I S, Haidara F C, Diallo F, Sanogo M, Sarro Y S, Kone A, Togo A C G, Traore A, Kodio M, Dosseh A, Rosenke K, de Wit E, Feldmann F, Ebihara H, Munster V J, Zoon K C, Feldmann H, Sow S
机构信息
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.
Bioinformatics and Computational Biosciences Branch, NIAID, NIH, Bethesda, MD 20892, USA.
出版信息
Science. 2015 Apr 3;348(6230):117-9. doi: 10.1126/science.aaa5646. Epub 2015 Mar 26.
The occurrence of Ebola virus (EBOV) in West Africa during 2013-2015 is unprecedented. Early reports suggested that in this outbreak EBOV is mutating twice as fast as previously observed, which indicates the potential for changes in transmissibility and virulence and could render current molecular diagnostics and countermeasures ineffective. We have determined additional full-length sequences from two clusters of imported EBOV infections into Mali, and we show that the nucleotide substitution rate (9.6 × 10(-4) substitutions per site per year) is consistent with rates observed in Central African outbreaks. In addition, overall variation among all genotypes observed remains low. Thus, our data indicate that EBOV is not undergoing rapid evolution in humans during the current outbreak. This finding has important implications for outbreak response and public health decisions and should alleviate several previously raised concerns.
2013年至2015年期间埃博拉病毒（EBOV）在西非的出现是前所未有的。早期报告表明，在此次疫情中，EBOV的变异速度是此前观察到的两倍，这表明其传播性和毒力可能发生变化，并可能使当前的分子诊断方法和应对措施失效。我们确定了马里两起输入性EBOV感染集群的更多全长序列，并表明核苷酸替代率（每年每个位点9.6×10^(-4)个替代）与在中非疫情中观察到的速率一致。此外，观察到的所有基因型之间的总体变异仍然较低。因此，我们的数据表明，在当前疫情期间，EBOV在人类中并未经历快速进化。这一发现对疫情应对和公共卫生决策具有重要意义，并应缓解此前提出的一些担忧。
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