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抗逆转录病毒疗法引入后住院的艾滋病毒/艾滋病患者的概况分析

Profile analysis of patients with HIV/AIDS hospitalized after the introduction of antiretroviral therapy.

作者信息

Nunes Altacílio Aparecido, Caliani Laís Scalone, Nunes Maíra Souza, da Silva Anderson Soares, de Mello Luane Marques

机构信息

Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil,

Hospital das Clínicas, FMRP, Universidade de São Paulo, Brasil.

出版信息

Cien Saude Colet. 2015 Oct;20(10):3191-8. doi: 10.1590/1413-812320152010.03062015.

Abstract

Since the introduction of highly active antiretroviral therapy (HAART) in 1996, there have been worldwide shifts in the causes of hospitalization for patients with HIV/AIDS. The aim of this study was to describe the characteristics of HIV/AIDS patient hospitalizations between 1997 and 2012. This cross-sectional study used a hospital database that centralizes records of admissions in 31 hospitals, both public and private, across 26 municipalities in the interior of São Paulo. In order to verify associations between the variables, we used the prevalence ratio (PR) and a 95% confidence interval. Among 9,797 adults and children, 10,696 admissions were registered, which was equal to 1.09 admissions per patient. Most (62%) of the patients were male, and the predominant age group was 21 and 50 years (63.5%). Mortality was higher among male patients from all age groups (PR= 1.42 [95% CI: 1.28-1.57]; p < 0.05). The main cause of hospitalization (54.5% of the total) was infectious disease, whether opportunistic or not. This was true, even in the post-HAART era. Furthermore, gender and age differences were noted in patient mortality rates.

摘要

自1996年引入高效抗逆转录病毒疗法(HAART)以来,全球范围内,感染艾滋病毒/艾滋病患者的住院原因已发生转变。本研究旨在描述1997年至2012年间艾滋病毒/艾滋病患者住院的特征。这项横断面研究使用了一个医院数据库,该数据库集中了圣保罗州内陆26个市的31家公立和私立医院的入院记录。为了验证变量之间的关联,我们使用了患病率比(PR)和95%置信区间。在9797名成人和儿童中,登记了10696次入院,即每位患者平均1.09次入院。大多数患者(62%)为男性,主要年龄组为21至50岁(63.5%)。各年龄组男性患者的死亡率更高(PR = 1.42 [95% CI:1.28 - 1.57];p < 0.05)。住院的主要原因(占总数的54.5%)是传染病,无论是否为机会性感染。即使在HAART时代之后,情况依然如此。此外,在患者死亡率方面还存在性别和年龄差异。

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