Liu Yi, Meng Ben, Zeng Chun, Wang Jingjie, Li Ying, Yin Ping, Sah Shambhu Kumar, Li Yongmei
From the Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
J Comput Assist Tomogr. 2015 Nov-Dec;39(6):866-75. doi: 10.1097/RCT.0000000000000299.
The aim of this study was to assess the baseline brain activity in patients with multiple sclerosis with simple spinal cord involvement (MS-SSCI) using regional amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) as indexes.
Resting-state functional magnetic resonance imaging data were acquired from 24 patients with MS-SSCI and 24 healthy controls and were processed using the Resting-State Functional Magnetic Resonance Imaging Data Analysis Toolkit. The relationships between expanded disability status scale scores, abnormal baseline brain activity, and disease duration were explored.
Compared with the controls, patients with MS-SSCI showed decreased ALFF in the right middle temporal gyrus, left middle frontal gyrus, lingual gyrus, and cuneus and increased ALFF in the right insula and bilateral supramarginal gyrus. Regions of abnormal fALFF were similar with those of ALFF. A significant correlation between expanded disability status scale scores and ALFF/fALFF was noted only in the right supramarginal gyrus.
Abnormal regional brain activity was detected in patients with MS-SSCI, which is probably due to spinal cord damage or potential brain damage.
本研究旨在以局部低频振幅（ALFF）和分数ALFF（fALFF）为指标，评估单纯脊髓受累的多发性硬化症（MS-SSCI）患者的基线脑活动。
从24例MS-SSCI患者和24名健康对照者获取静息态功能磁共振成像数据，并使用静息态功能磁共振成像数据分析工具包进行处理。探讨扩展残疾状态量表评分、异常基线脑活动和病程之间的关系。
与对照组相比，MS-SSCI患者右侧颞中回、左侧额中回、舌回和楔叶的ALFF降低，右侧岛叶和双侧缘上回的ALFF升高。fALFF异常区域与ALFF异常区域相似。仅在右侧缘上回发现扩展残疾状态量表评分与ALFF/fALFF之间存在显著相关性。
在MS-SSCI患者中检测到区域脑活动异常，这可能是由于脊髓损伤或潜在的脑损伤所致。
