协同配体结合的双态模型和序列模型之间的区别。
Distinctions between the two-state and sequential models for cooperative ligand binding.
作者信息
Gibson R E, Levin S A
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):139-43. doi: 10.1073/pnas.74.1.139.
Abstract
The two-state and sequential models for positive cooperativity in ligand binding can produce significantly different theoretical binding curves when presented in a Scatchard plot. The conditions that produce the greatest differences have been examined. The theoretical differences have been used to select the two-state model as the best model for describing the binding of acetylcholine to acetylcholine receptors that have been solubilized by Triton X-100 and sodium cholate.
摘要
在Scatchard图中呈现时，用于描述配体结合中正向协同性的双态模型和顺序模型可产生显著不同的理论结合曲线。已经研究了产生最大差异的条件。利用理论差异选择双态模型作为描述乙酰胆碱与经Triton X-100和胆酸钠溶解的乙酰胆碱受体结合的最佳模型。
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