协同配体结合的双态模型和序列模型之间的区别。
Distinctions between the two-state and sequential models for cooperative ligand binding.
作者信息
Gibson R E, Levin S A
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):139-43. doi: 10.1073/pnas.74.1.139.
Abstract
The two-state and sequential models for positive cooperativity in ligand binding can produce significantly different theoretical binding curves when presented in a Scatchard plot. The conditions that produce the greatest differences have been examined. The theoretical differences have been used to select the two-state model as the best model for describing the binding of acetylcholine to acetylcholine receptors that have been solubilized by Triton X-100 and sodium cholate.
摘要
在Scatchard图中呈现时，用于描述配体结合中正向协同性的双态模型和顺序模型可产生显著不同的理论结合曲线。已经研究了产生最大差异的条件。利用理论差异选择双态模型作为描述乙酰胆碱与经Triton X-100和胆酸钠溶解的乙酰胆碱受体结合的最佳模型。
相似文献
1
Distinctions between the two-state and sequential models for cooperative ligand binding.协同配体结合的双态模型和序列模型之间的区别。
Proc Natl Acad Sci U S A. 1977 Jan;74(1):139-43. doi: 10.1073/pnas.74.1.139.
2
Ligand interactions with the acetylcholine receptor from Torpedo californica. Extensions of the allosteric model for cooperativity to half-of-site activity.来自加州电鳐的乙酰胆碱受体的配体相互作用。协同变构模型对半位点活性的扩展。
Biochemistry. 1976 Aug 24;15(17):3890-901. doi: 10.1021/bi00662a037.
3
Conservation of the kinetic and allosteric properties of the acetylcholine receptor in its Na cholate soluble 9 S form : effect of lipids.乙酰胆碱受体在其胆酸钠可溶性9S形式下的动力学和别构性质的保守性：脂质的影响
Biochem Biophys Res Commun. 1980 Mar 13;93(1):127-33. doi: 10.1016/s0006-291x(80)80255-5.
4
Calculation of binding isotherms when ligand and receptor are in different volumes of distribution.
Anal Biochem. 1980 Oct;108(1):64-71. doi: 10.1016/0003-2697(80)90692-2.
5
Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.全氢组氨力农毒素：一种乙酰胆碱受体离子电导调节剂的潜在配体。
Proc Natl Acad Sci U S A. 1977 May;74(5):2172-6. doi: 10.1073/pnas.74.5.2172.
6
Specific binding of perhydrohistrionicotoxin to Torpedo acetylcholine receptor.全氢组氨酰胆碱毒素与电鳐乙酰胆碱受体的特异性结合。
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2576-9. doi: 10.1073/pnas.76.6.2576.
7
Structural and functional properties of the acetylcholine receptor protein in its purified and membrane-bound states.乙酰胆碱受体蛋白在其纯化状态和膜结合状态下的结构与功能特性。
Annu Rev Biochem. 1978;47:317-57. doi: 10.1146/annurev.bi.47.070178.001533.
8
Characterization and isolation of cholinergic receptors from electric tissue. Binding properties of acetylcholine receptors.从电组织中鉴定和分离胆碱能受体。乙酰胆碱受体的结合特性。
Neurosci Res Program Bull. 1973 Jun;11(3):242-6.
9
Biochemical studies on Torpedo californica acetylcholine receptors.加州电鳐乙酰胆碱受体的生化研究。
J Supramol Struct. 1973;1(4):360-7. doi: 10.1002/jss.400010414.
10
Effect ofcholinergic ligands on the lipids of acetylcholine receptor-rich membrane preparations from Torpedo californica.胆碱能配体对来自加州电鳐的富含乙酰胆碱受体的膜制剂脂质的影响。
J Supramol Struct. 1976;4(3):373-80. doi: 10.1002/jss.400040308.
引用本文的文献
1
On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.关于GPCR领域不断扩展的术语：受体嵌合体和受体异聚体的含义。
J Recept Signal Transduct Res. 2010 Oct;30(5):287-303. doi: 10.3109/10799891003786226.
2
Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines.血凝素表位的差异中和效率、抗体干扰与流感疫苗设计
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8701-6. doi: 10.1073/pnas.0903427106. Epub 2009 May 13.
3
Biochemical investigations of ionic channels in excitable membranes.可兴奋膜中离子通道的生化研究。
Mol Cell Biochem. 1977 Dec 29;18(2-3):151-72. doi: 10.1007/BF00280280.
本文引用的文献
1
The Oxygen Equilibrium of Hemoglobin and Its Structural Interpretation.血红蛋白的氧平衡及其结构解析
Proc Natl Acad Sci U S A. 1935 Apr;21(4):186-91. doi: 10.1073/pnas.21.4.186.
2
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.关于别构转变的本质：一个合理的模型。
J Mol Biol. 1965 May;12:88-118. doi: 10.1016/s0022-2836(65)80285-6.
3
Comparison of experimental binding data and theoretical models in proteins containing subunits.含亚基蛋白质中实验结合数据与理论模型的比较。
Biochemistry. 1966 Jan;5(1):365-85. doi: 10.1021/bi00865a047.
4
Extensions of the allosteric model for hemoglobin. II. Consequences of functional nonequivalence of the alpha and beta chains.血红蛋白别构模型的扩展。II. α链和β链功能不等价的后果。
Biochemistry. 1974 Nov 19;13(24):4998-5002. doi: 10.1021/bi00721a020.
5
Kinetics of allosteric enzymes.别构酶的动力学
Annu Rev Biophys Bioeng. 1974;3(0):1-33. doi: 10.1146/annurev.bb.03.060174.000245.
6
A general method for the quantitative determination of saturation curves for multisubunit proteins.一种用于定量测定多亚基蛋白质饱和曲线的通用方法。
Biochemistry. 1970 Aug 18;9(17):3325-36. doi: 10.1021/bi00819a006.
7
Conversion of high affinity acetylcholine receptor from Torpedo californica electroplax to an altered form.加州电鳐电板中高亲和力乙酰胆碱受体向一种改变形式的转化。
Arch Biochem Biophys. 1975 Aug;169(2):458-63. doi: 10.1016/0003-9861(75)90188-5.
8
The control of pyruvate kinase of Escherichia coli. Binding of substrate and allosteric effectors to the enzyme activated by fructose 1,6-bisphosphate.大肠杆菌丙酮酸激酶的调控。底物和变构效应剂与由1,6-二磷酸果糖激活的该酶的结合。
Biochemistry. 1976 Jan 27;15(2):277-82. doi: 10.1021/bi00647a006.
9
Cooperative interactions of hemoglobin.血红蛋白的协同相互作用。
Annu Rev Biochem. 1975;44:209-32. doi: 10.1146/annurev.bi.44.070175.001233.
10
Subunit interactions in yeast glyceraldehyde-3-phosphate dehydrogenase.
Biochemistry. 1975 Dec 16;14(25):5428-37. doi: 10.1021/bi00696a008.
Zotero 插件