Kawczyk-Krupka A, Wawrzyniec K, Musiol S K, Potempa M, Bugaj A M, Sieroń A
School of Medicine with the Division of Dentistry in Zabrze, Department and Clinic of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.
Department of Internal Diseases, 11 Listopada 48, 28-200 Staszów, Poland.
Photodiagnosis Photodyn Ther. 2015 Dec;12(4):567-74. doi: 10.1016/j.pdpdt.2015.10.001. Epub 2015 Oct 20.
Photodynamic therapy (PDT) is well known for its direct cytotoxicity of the free radical-producing photochemical reaction, indirect mechanisms of action including modulation of intrinsic anti-tumour immune activity, and occlusion of pathologically altered tumour vessels leading to tumour ischaemia. The aim of this work is to critically review the evidence base for the use of vascular targeted PDT (VTP) to treat low-risk prostate cancer, and to discuss perspectives and challenges yet to be overcome. A brief general overview of focal prostate cancer therapy was provided, followed by a discussion of both basic and clinical research pertaining to prostate cancer VTP, with a focus on the palladium-based WST-09 and WST-11 photosensitisers.
Literature on VTP for prostate cancer with the fallowing medical subject headings search terms: prostate cancer, photodynamic therapy, vascular targeted photodynamic therapy, bacteriopheophorbide were reviewed. The articles were selected by their relevance to the topic.
The clinical and basic research data available to date show much promise for WST-09, and WST-11 based VTP eventually joining the standard urologist's armamentarium against prostate cancer. With good reported tolerability and efficacy VTP can be proposed as an intermediate treatment for local low risk disease, halfway between watchful waiting and radical therapy.
光动力疗法（PDT）以其产生自由基的光化学反应的直接细胞毒性、包括调节内在抗肿瘤免疫活性在内的间接作用机制以及阻塞病理改变的肿瘤血管导致肿瘤缺血而闻名。这项工作的目的是严格审查使用血管靶向光动力疗法（VTP）治疗低风险前列腺癌的证据基础，并讨论有待克服的观点和挑战。首先简要概述了局灶性前列腺癌治疗，然后讨论了与前列腺癌VTP相关的基础和临床研究，重点是基于钯的WST - 09和WST - 11光敏剂。
回顾了关于前列腺癌VTP的文献，搜索词如下：前列腺癌、光动力疗法、血管靶向光动力疗法、细菌叶绿素。根据文章与主题的相关性进行筛选。
迄今为止可获得的临床和基础研究数据表明，基于WST - 09和WST - 11的VTP最终有望加入泌尿科医生对抗前列腺癌的标准武器库。鉴于良好的耐受性和疗效报告，VTP可作为局部低风险疾病的中间治疗方法，介于密切观察等待和根治性治疗之间。
