Son Jun Seok, Kim Jang Hoe, Kim Hee-Jae, Yoon Dong Hyun, Kim Jin-Soo, Song Han Sol, Song Wook
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
Institute on Aging, Seoul National University, Seoul, Korea.
Muscle Nerve. 2016 Jun;53(6):951-7. doi: 10.1002/mus.24940. Epub 2016 Feb 4.
Secreted protein acidic and rich in cysteine (SPARC) is associated with skeletal muscle atrophy. Here we examined possibility that resistance training could regulate SPARC expression in muscle atrophy in an immobilized hindlimb model.
Sprague-Dawley rats underwent resistance ladder training and hindlimb immobilization. Cross sectional area and grip strength were measured. SPARC protein levels in the plantaris and soleus, and serum after exercise and immobilization were then analyzed.
Resistance training decreased body weight (P < 0.001) and increased muscle quality (P < 0.001). In the plantaris, muscle atrophy (31.82%) and up-regulated SPARC expression (P < 0.05) after immobilization were alleviated by resistance training.
Resistance training led to suppression of SPARC expression in the plantaris and showed a pretraining effect in atrophied rat muscle. Thus, SPARC may play a pivotal role in muscle homeostasis. Muscle Nerve 53: 951-957, 2016.
富含半胱氨酸的酸性分泌蛋白（SPARC）与骨骼肌萎缩相关。在此，我们研究了阻力训练能否在固定后肢模型的肌肉萎缩中调节SPARC表达。
将Sprague-Dawley大鼠进行阻力阶梯训练和后肢固定。测量横截面积和握力。然后分析运动和固定后比目鱼肌和跖肌中的SPARC蛋白水平以及血清中的SPARC蛋白水平。
阻力训练使体重降低（P < 0.001），肌肉质量增加（P < 0.001）。在跖肌中，固定后出现的肌肉萎缩（31.82%）和SPARC表达上调（P < 0.05）通过阻力训练得到缓解。
阻力训练导致跖肌中SPARC表达受到抑制，并在萎缩的大鼠肌肉中显示出训练前效应。因此，SPARC可能在肌肉稳态中起关键作用。《肌肉与神经》53: 951 - 957, 2016年。
