Attrill Helen, Falls Kathleen, Goodman Joshua L, Millburn Gillian H, Antonazzo Giulia, Rey Alix J, Marygold Steven J
Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Nucleic Acids Res. 2016 Jan 4;44(D1):D786-92. doi: 10.1093/nar/gkv1046. Epub 2015 Oct 13.
Many publications describe sets of genes or gene products that share a common biology. For example, genome-wide studies and phylogenetic analyses identify genes related in sequence; high-throughput genetic and molecular screens reveal functionally related gene products; and advanced proteomic methods can determine the subunit composition of multi-protein complexes. It is useful for such gene collections to be presented as discrete lists within the appropriate Model Organism Database (MOD) so that researchers can readily access these data alongside other relevant information. To this end, FlyBase (flybase.org), the MOD for Drosophila melanogaster, has established a 'Gene Group' resource: high-quality sets of genes derived from the published literature and organized into individual report pages. To facilitate further analyses, Gene Group Reports also include convenient download and analysis options, together with links to equivalent gene groups at other databases. This new resource will enable researchers with diverse backgrounds and interests to easily view and analyse acknowledged D. melanogaster gene sets and compare them with those of other species.
许多出版物描述了具有共同生物学特性的基因集或基因产物。例如，全基因组研究和系统发育分析可识别序列相关的基因；高通量遗传和分子筛选揭示功能相关的基因产物；先进的蛋白质组学方法能够确定多蛋白复合物的亚基组成。将这些基因集作为离散列表呈现在适当的模式生物数据库（MOD）中很有用，这样研究人员就能在获取其他相关信息的同时方便地访问这些数据。为此，果蝇的模式生物数据库FlyBase（flybase.org）建立了一个“基因组”资源：从已发表文献中获取的高质量基因集，并组织成单独的报告页面。为便于进一步分析，基因组报告还包括便捷的下载和分析选项，以及指向其他数据库中同等基因组的链接。这个新资源将使具有不同背景和兴趣的研究人员能够轻松查看和分析公认的黑腹果蝇基因集，并将它们与其他物种的基因集进行比较。
