Holliday R
Trends Genet. 1989 Feb;5(2):42-5. doi: 10.1016/0168-9525(89)90020-6.
A general characteristic of tumour cells is their unstable karyotype. It is suggested here that maintenance of the normal diploid cell depends on the presence of two copies of specific genes; a change in gene dosage of one or more of these genes, by chromosome nondisjunction or rearrangement, may trigger a general loss of accuracy in chromosome segregation at mitosis.
肿瘤细胞的一个普遍特征是其染色体核型不稳定。本文提出，正常二倍体细胞的维持依赖于特定基因的两个拷贝的存在；通过染色体不分离或重排，这些基因中的一个或多个基因剂量的改变可能会引发有丝分裂时染色体分离准确性的普遍丧失。
