中性粒细胞与淋巴细胞比值：预测急性A型主动脉夹层患者院内死亡率的新型标志物。
Neutrophil to lymphocyte ratio: a novel marker for predicting hospital mortality of patients with acute type A aortic dissection.
作者信息
Kalkan Mehmet Emin, Kalkan Ali Kemal, Gündeş Ahmet, Yanartaş Mehmed, Oztürk Semi, Gurbuz Ahmet Seyfeddin, Ozturk Derya, Iyigun Taner, Akcakoyun Mustafa, Emiroglu Mehmet Yunus, Tuncer Mehmet Altuğ, Koksal Cengiz
机构信息
1 Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
2 Mehmet Akif Ersoy Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
出版信息
Perfusion. 2017 May;32(4):321-327. doi: 10.1177/0267659115590625. Epub 2015 Oct 14.
INTRODUCTION
The inflammatory process has been reported to be associated with aortic dissection (AD) from the development to the prognosis. The aim of the study was to investigate a relationship between the neutrophil to lymphocyte ratio (NLR) and in-hospital outcomes in patients with acute aortic dissection (AAD) who underwent surgical repair.
METHODS
One hundred and eighty-four patients who were admitted with the diagnosis of type A AAD who underwent surgical repair at two large tertiary hospitals. According to their NLR, 91 patients had high NLR (>6.0) and 93 patients had low NLR (⩽6.0).
RESULTS
The frequency of major bleeding, hospital-related infection, multi-organ dysfunction and mortality in hospital were higher in the high NLR group compared to the low NLR group. NLR, WBC count and operation duration were found to be independent predictors for in-hospital mortality.
CONCLUSIONS
The novel inflammatory marker NLR may be used to predict worse outcomes and hospital mortality in patients with AAD treated by surgical repair.
引言
据报道，从主动脉夹层（AD）的发生到预后，炎症过程与之相关。本研究的目的是调查接受手术修复的急性主动脉夹层（AAD）患者的中性粒细胞与淋巴细胞比值（NLR）与住院结局之间的关系。
方法
184例被诊断为A型主动脉夹层并在两家大型三级医院接受手术修复的患者。根据NLR，91例患者NLR较高（>6.0），93例患者NLR较低（≤6.0）。
结果
与NLR较低的组相比，NLR较高的组主要出血、医院相关感染、多器官功能障碍和住院死亡率的发生率更高。发现NLR、白细胞计数和手术持续时间是住院死亡率的独立预测因素。
结论
新型炎症标志物NLR可用于预测接受手术修复治疗的AAD患者的较差结局和医院死亡率。
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