Rajabi Zahra, Soltan Dallal Mohammad Mehdi
Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, IR Iran.
Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, IR Iran ; Department of Pathobiology, Tehran University of Medical Sciences, Tehran, IR Iran.
Jundishapur J Microbiol. 2015 Aug 27;8(8):e19654. doi: 10.5812/jjm.19654v2. eCollection 2015 Aug.
Infections are considered as one of the main factors of neonatal mortality, especially in developing countries. Blood and urine infections are one of the most prevalent infectious factors among the infants. On the other hand, resistance against antimicrobial factors is one of the major problems in the world, and it is important to be informed about antibiotic resistance pattern of microorganisms for treatment of infections.
The aim of this study was to examine the bacterial strains causing blood and urinary tract infections in Neonatal Intensive Care Unit (NICU) and determine their antibiotic resistance pattern.
In this study, the microorganisms of 150 blood and urine samples of infants hospitalized in NICUs of Imam Hussein Hospital, Children Hospital Center and Bahrami Hospital in Tehran, Iran, were collected during seven months, and the antimicrobial resistance patterns of the isolates were studied by the Kirby-Bauer test.
During the seven-month study on 105 samples, including 85 (81%) urine samples and 20 (19%) blood samples, 81 samples (77.1%) were Gram-negative and 24 (22.9%) were Gram-positive organisms. Klebsiella pneumoniae (30.5%) was the most common Gram-negative microorganisms and Staphylococcus epidermidis (11.4%) was the most prevalent Gram-positive microorganisms. The most antimicrobial susceptibility in Gram-negative microorganisms was shown to ciprofloxacin (84.2%) and in Gram- positive ones was shown to vancomycin (83.3%).
This results of the study show that the most contamination in NICUs is from Gram-negative bacteria and ciprofloxacin is the most effective antibiotic for treatment. Thus, the control of infections in NICUs in hospitals is very important.
感染被认为是新生儿死亡的主要因素之一，尤其是在发展中国家。血液和尿液感染是婴儿中最普遍的感染因素之一。另一方面，对抗菌因子的耐药性是全球主要问题之一，了解微生物的抗生素耐药模式对于感染治疗很重要。
本研究旨在检测新生儿重症监护病房（NICU）中引起血液和尿路感染的细菌菌株，并确定其抗生素耐药模式。
在本研究中，在七个月的时间里收集了伊朗德黑兰伊玛目侯赛因医院、儿童医院中心和巴赫拉米医院NICU住院婴儿的150份血液和尿液样本中的微生物，并通过 Kirby-Bauer 试验研究分离株的抗菌耐药模式。
在对105份样本进行的为期七个月的研究中，包括85份（81%）尿液样本和20份（19%）血液样本，81份样本（77.1%）为革兰氏阴性菌，24份（22.9%）为革兰氏阳性菌。肺炎克雷伯菌（30.5%）是最常见的革兰氏阴性微生物，表皮葡萄球菌（11.4%）是最普遍的革兰氏阳性微生物。革兰氏阴性微生物中对环丙沙星的抗菌敏感性最高（84.2%），革兰氏阳性微生物中对万古霉素的抗菌敏感性最高（83.3%）。
本研究结果表明，NICU中污染最严重的是革兰氏阴性菌且环丙沙星是最有效的治疗抗生素。因此，医院NICU中感染的控制非常重要。
