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线粒体苹果酸脱氢酶的遗传控制:染色体片段重复的证据。

Genetic control of mitochondrial malate dehydrogenases: evidence for duplicated chromosome segments.

作者信息

Yang N S, Sorenson J C, Scandalios J G

出版信息

Proc Natl Acad Sci U S A. 1977 Jan;74(1):310-4. doi: 10.1073/pnas.74.1.310.

Abstract

The genetic control of the major mitochondrial isoenzymes of malate dehydrogenase (L-malate:NAD+ oxidoreductase; EC 1.1.1.37) has been investigated in Zea mays. The mitochondrial isozymes are coded at four nuclear gene loci. Two of the loci (mdh1 and mdh2) are diallelic and tightly linked. The other two loci (mdh3 and mdh4) appear to have arisen by duplication of the chromosome segment carrying mdh1 and mdh2, but are not linked to them. The segregation of such a duplicate segment can explain anomalous backcross and F2 segregation ratios.

摘要

已在玉米中研究了苹果酸脱氢酶(L-苹果酸:NAD⁺氧化还原酶;EC 1.1.1.37)主要线粒体同工酶的遗传控制。线粒体同工酶由四个核基因位点编码。其中两个位点(mdh1和mdh2)是双等位基因且紧密连锁。另外两个位点(mdh3和mdh4)似乎是通过携带mdh1和mdh2的染色体片段重复产生的,但与它们不连锁。这样一个重复片段的分离可以解释异常回交和F2分离比。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/114f/393249/b9bce78036e3/pnas00023-0318-a.jpg

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