免疫中的细胞周期调节因子与细胞死亡
Cell-Cycle Regulators and Cell Death in Immunity.
作者信息
Zebell Sophia G, Dong Xinnian
机构信息
Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA.
Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA.
出版信息
Cell Host Microbe. 2015 Oct 14;18(4):402-7. doi: 10.1016/j.chom.2015.10.001.
Abstract
Various cell death mechanisms are integral to host defense in both plants and mammals. Plant defense against biotrophic pathogens is associated with programmed cell death (PCD) of the infected cell. This effector-triggered PCD is partly analogous to pyroptosis, an inflammatory host cell death process that plays a crucial role in defense against microbial infections in mammals. Plant effector-triggered PCD also shares with mammalian apoptosis the involvement of cell-cycle regulators as signaling components. Here we explore the similarities between these different cell death programs as they relate to host defense and their relationship to the cell cycle.
摘要
多种细胞死亡机制在植物和哺乳动物的宿主防御中都不可或缺。植物对活体营养型病原体的防御与受感染细胞的程序性细胞死亡（PCD）有关。这种效应物触发的PCD部分类似于细胞焦亡，细胞焦亡是一种炎症性宿主细胞死亡过程，在哺乳动物抵御微生物感染中起关键作用。植物效应物触发的PCD在作为信号成分的细胞周期调节因子的参与方面也与哺乳动物的细胞凋亡有共同之处。在此，我们探讨这些不同细胞死亡程序之间与宿主防御相关的相似性以及它们与细胞周期的关系。
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