Dansingani Kunal K, Freund K Bailey
Ophthalmic Surg Lasers Imaging Retina. 2015 Oct;46(9):907-12. doi: 10.3928/23258160-20151008-02.
To demonstrate a vascular pattern seen on optical coherence tomography angiography (OCTA) that appears to correlate with reduced rates of geographic atrophy (GA) in eyes receiving long-term anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (AMD).
Non-consecutive, retrospective cohort study. Patients were included if they had received more than 50 anti-VEGF injections during a period of at least 4 years for neovascular AMD in at least one eye, with absence or minimal progression of GA. Clinical charts and imaging were reviewed retrospectively; study eyes underwent OCTA.
Nine eyes of eight patients were included. Mean age was 82 years, and mean follow-up of study eyes 9.1 years; study eyes received a mean of 65.8 injections. OCTA revealed tangled networks of neovessels associated with type 1 lesions.
With prolonged anti-VEGF treatment, GA appears to occur less commonly in eyes with type 1 neovascularization. OCTA shows mature tangled vessels with substantial flow within type 1 lesions. Mature, tangled networks may be associated with a decreased likelihood of developing GA despite the presence of choriocapillaris atrophy.
展示光学相干断层扫描血管造影（OCTA）上所见的一种血管模式，该模式似乎与接受长期抗血管内皮生长因子（VEGF）治疗的新生血管性年龄相关性黄斑变性（AMD）患者眼中地图样萎缩（GA）发生率降低相关。
非连续回顾性队列研究。纳入标准为至少一只眼因新生血管性AMD在至少4年期间接受了超过50次抗VEGF注射且GA无进展或进展极小的患者。对临床病历和影像学资料进行回顾性分析；研究眼接受OCTA检查。
纳入8例患者的9只眼。平均年龄82岁，研究眼平均随访9.1年；研究眼平均接受65.8次注射。OCTA显示与1型病变相关的新生血管缠结网络。
长期抗VEGF治疗后，1型新生血管化的眼中GA似乎较少见。OCTA显示1型病变内有大量血流的成熟缠结血管。尽管存在脉络膜毛细血管萎缩，但成熟的缠结网络可能与发生GA的可能性降低有关。
