妊娠肝内胆汁淤积症发病机制中的免疫学基础。
Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy.
作者信息
Larson Spencer P, Kovilam Oormila, Agrawal Devendra K
机构信息
a Center for Clinical & Translational Science , Creighton University School of Medicine , Omaha , NE , USA.
b Department of Obstetrics and Gynecology , Creighton University School of Medicine , Omaha , NE , USA.
出版信息
Expert Rev Clin Immunol. 2016;12(1):39-48. doi: 10.1586/1744666X.2016.1101344. Epub 2015 Oct 15.
Abstract
Intrahepatic cholestasis of pregnancy poses a great risk to both maternal and fetal health. Despite extensive research, much of the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this literature review, we have critically reviewed the current literature regarding the changes in the immune system and the potential effects of immunological changes in the management of the patient. The current treatment, ursodeoxycholic acid, is also discussed along with potential combination therapies and future directions for research.
摘要
妊娠期肝内胆汁淤积症对母婴健康构成极大风险。尽管进行了广泛研究，但该疾病的许多发病机制仍不清楚。已注意到妊娠期肝内胆汁淤积症患者体内胆汁酸的增加会导致免疫系统从正常介导的TH2反应转变为更倾向于TH1的反应。在这篇文献综述中，我们严格审查了有关免疫系统变化以及免疫变化在患者管理中的潜在影响的当前文献。还讨论了目前的治疗药物熊去氧胆酸以及潜在的联合治疗方法和未来的研究方向。
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