镍催化脂肪族酰胺与噻吩的直接C(sp(3))-H芳基化反应
Nickel-Catalyzed Direct C (sp(3))-H Arylation of Aliphatic Amides with Thiophenes.
作者信息
Wang Xie, Zhu Longzhi, Chen Sihai, Xu Xinhua, Au Chak-Tong, Qiu Renhua
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha, 410082, P.R. China.
Department of Chemistry, Hong Kong Baptist University , Hong Kong, P.R. China.
出版信息
Org Lett. 2015 Nov 6;17(21):5228-31. doi: 10.1021/acs.orglett.5b02572. Epub 2015 Oct 15.
Nickel-catalyzed heteroarylation of the inactive methyl C(sp(3))-H bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various kinds of alkyl-substituted heteroarenes.
本文描述了镍催化脂肪族酰胺中惰性甲基C(sp(3))-H键与杂芳烃的杂芳基化反应。该方法利用了8-氨基喹啉基部分的螯合辅助作用。该合成反应对官能团具有良好的耐受性，可用于构建各种烷基取代的杂芳烃。
Zotero 插件