表面活性剂滴注对严重呼吸窘迫综合征的急性影响。
Acute effects of instillation of surfactant in severe respiratory distress syndrome.
作者信息
Halliday H L, McCord F B, McClure B G, Reid M M
机构信息
Department of Child Health, Queen's University of Belfast.
出版信息
Arch Dis Child. 1989 Jan;64(1 Spec No):13-6. doi: 10.1136/adc.64.1_spec_no.13.
Abstract
Doppler ultrasound measurements of pulmonary blood flow in 20 babies with severe respiratory distress syndrome treated in a randomised controlled trial of surfactant replacement showed that the immediate improvement of oxygenation was not associated with a significant increase in pulmonary blood flow. Reduction in ventilator settings and increases in the extent of chest wall movements measured by a cardiorespiratory monitor suggested that the improvement after surfactant had been given was a result of alveolar stabilisation and increased pulmonary compliance. Further simultaneous studies of pulmonary blood flow and pulmonary compliance are needed to confirm these findings.
摘要
在一项表面活性剂替代的随机对照试验中，对20名患有严重呼吸窘迫综合征的婴儿进行了肺血流的多普勒超声测量，结果显示氧合的即刻改善与肺血流的显著增加无关。通过心肺监测仪测量的呼吸机设置的降低和胸壁运动范围的增加表明，给予表面活性剂后的改善是肺泡稳定和肺顺应性增加的结果。需要进一步同时研究肺血流和肺顺应性以证实这些发现。
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