Alverson D C, Eldridge M, Dillon T, Yabek S M, Berman W
J Pediatr. 1982 Jul;101(1):46-50. doi: 10.1016/s0022-3476(82)80178-9.
Mean blood flow velocity (VAo) in the ascending aorta was measured noninvasively in 33 children, ages 3 days to 17 years, by pulsed Doppler technique at the time of cardiac catheterization. Measurements were made from a suprasternal approach with a portable, range-gated device. The ascending aortic diameter was determined echocardiographically and aortic cross sectional area calculated (A = pi d2/4 cm2). Aortic flow (QAo) was computed from Doppler recordings: QAo (ml/minute) = VAo (cm/second) X A (cm2) X 60 (second/minute). Values were compared with cardiac outputs determined according to the Fick principle, using measured oxygen consumption calculated oxygen capacity, and oxygen saturation. Subjects with aortic valve abnormalities or left ventricular outflow tract obstruction were excluded from study. Agreement between the two methods was excellent (linear regression r = 0.98, slope = 1.07, y-intercept = -4.5 ml, range 403 to 5.540 ml/minute). The Doppler technique is a quick, noninvasive, and accurate method of determining ascending aortic blood flow in neonates and children.
在33名年龄从3天至17岁的儿童进行心导管检查时，采用脉冲多普勒技术经胸骨上入路，使用便携式距离选通装置，对升主动脉的平均血流速度（VAo）进行了无创测量。通过超声心动图确定升主动脉直径，并计算主动脉横截面积（A = πd²/4 cm²）。根据多普勒记录计算主动脉血流量（QAo）：QAo（毫升/分钟）= VAo（厘米/秒）×A（平方厘米）×60（秒/分钟）。将这些值与根据Fick原理测定的心输出量进行比较，Fick原理使用测量的氧耗量、计算的氧容量和氧饱和度。患有主动脉瓣异常或左心室流出道梗阻的受试者被排除在研究之外。两种方法之间的一致性非常好（线性回归r = 0.98，斜率 = 1.07，截距 = -4.5毫升，范围为403至5540毫升/分钟）。多普勒技术是一种快速、无创且准确的测定新生儿和儿童升主动脉血流量的方法。
