Gao Xiaoyan, Zhou Haiwei, Liu Hong, Fu Shihong, Wang Huanyu, Guo Zhenyang, Li Xiaolong, Liang Guodong
Bing Du Xue Bao. 2015 May;31(3):264-8.
To explore the spatial distribution mechanism of Japanese encephalitis virus (JEV), PhyML v3.0 was used to build phylogenetic tree using JEV sequences in the dataset. PAUP v4.0 and Migrapyhla softz ware were then used to analyze the migration events. The results showed that a total of 95 migration events were observed during the dispersal of JEV throughout Asia. Further analysis revealed that Thailand, and several Chinese provinces (including Shandong, Shanghai, Sichuan and Yunnan), were the main migration sources of JEV. JEV spread from these migration sources as follows: from Thailand to Australia, Cambodia, Tibet and India; from Shanghai to eastern coastal Asian regions and Yunnan; from Shandong to Korea, Zhejiang, Hubei, Shanxi and Liaoning; from Sichuan mainly to inland regions of China, as well as Vietnam and Japan; and from Yunnan to Zhejiang. This study indicated that frequent migration events occurred during the dispersal of JEV in the Asia and Pacific regions, and that Thailand, Shandong, Shanghai, Sichuan and Yunnan were the sources of JEV dispersal.
为探究日本脑炎病毒（JEV）的空间分布机制，使用PhyML v3.0软件基于数据集中的JEV序列构建系统发育树。随后使用PAUP v4.0和Migrapyhla软件分析迁移事件。结果显示，在JEV在亚洲传播过程中共观察到95次迁移事件。进一步分析表明，泰国以及中国的几个省份（包括山东、上海、四川和云南）是JEV的主要迁移源。JEV从这些迁移源传播的情况如下：从泰国传播到澳大利亚、柬埔寨、西藏和印度；从上海传播到亚洲东部沿海地区和云南；从山东传播到韩国、浙江、湖北、山西和辽宁；从四川主要传播到中国内陆地区以及越南和日本；从云南传播到浙江。本研究表明，在亚太地区JEV传播过程中发生了频繁的迁移事件，泰国、山东、上海、四川和云南是JEV传播的源头。
