INSERM U1151 eq. 11, Université Paris Descartes - Sorbonne Paris Cité, Laboratory of Microbiology, Necker-Enfants Malades Hospital, Paris, France.
INSERM UMR 1163, Laboratory of Genetic Skin Diseases: from Disease Mechanism to Therapies, Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France.
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S66-9. doi: 10.1016/j.jaad.2015.07.040.
Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases.
坏疽性脓皮病、重度痤疮和化脓性汗腺炎（PASH）综合征可能难以治疗，其特征是反复发作。抗生素治疗和手术的联合应用可以成功治疗该综合征。需要进行急性治疗，但也需要维持治疗以预防疾病复发。对抗生素治疗的反应具有启发性，提出了宿主反应改变的问题。迄今为止，一些病例报告支持手术和药物治疗，但需要进行对照研究并进行长期随访，以证实对个别病例观察到的初步数据。
