对报告近期无肛交行为的感染艾滋病毒的男男性行为者进行肛门人乳头瘤病毒检测：肛门癌检查（ACE）研究的基线分析

Anal HPV detection in men who have sex with men living with HIV who report no recent anal sexual behaviours: baseline analysis of the Anal Cancer Examination (ACE) study.

作者信息

Ong Jason J, Chen Marcus, Tabrizi Sepehr N, Cornall Alyssa, Garland Suzanne M, Jin Fengyi, Tee B K, Eu Beng, Fairley Christopher K

机构信息

Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.

Melbourne Sexual Health Centre, Carlton, Victoria, Australia Central Clinical School, Monash University, Clayton, Victoria, Australia.

出版信息

Sex Transm Infect. 2016 Aug;92(5):368-70. doi: 10.1136/sextrans-2015-052121. Epub 2015 Oct 15.

DOI:10.1136/sextrans-2015-052121

PMID:26472920

Abstract

OBJECTIVES

Men who have sex with men (MSM) living with HIV are at high risk of infection with high-risk human papillomavirus (HPV), the cause of anal cancer. We assess whether anal HPV DNA detection is related to recent anal sexual activity, what types of anal sexual activity or the persistence of HPV genotypes.

METHODS

We analysed anal swabs taken at the baseline of a 2-year prospective anal cancer screening study of MSM living with HIV from four HIV clinics in Melbourne, Australia. Anal HPV detection was stratified by age and anal sexual behaviours.

RESULTS

281 anal swabs were included in the analysis. The majority (80%, 95% CI 75 to 84) of men were positive for any HPV; 59% (95% CI 53 to 65) were positive for high-risk HPV (hr-HPV) genotypes; and 31% (95% CI 26 to 36) men were positive for HPV 16 and/or 18 with no significant differences according to age groups (p>0.261). In men who reported no receptive anal sexual activity in the last six months (22%), hr-HPV was found in 53% (95% CI 41 to 65) for no anal sexual activity versus. 60% (95% CI 54 to 67) for anal sexual activity (p=0.320). HPV 16 and/or 18 was found in 26% (95% CI 16 to 38) for no anal sexual activity versus. 32% (95% CI 27 to 39) for anal sexual activity (p=0.320).

CONCLUSIONS

Anal HPV in MSM living with HIV is detected in the majority of men throughout all age groups. Anal HPV detection remains high even in men reporting no anal sexual activity in the preceding six months.

摘要

目的

感染人类免疫缺陷病毒（HIV）的男男性行为者（MSM）感染高危型人乳头瘤病毒（HPV，肛门癌的病因）的风险很高。我们评估肛门HPV DNA检测是否与近期肛交行为、肛交行为类型或HPV基因型的持续性有关。

方法

我们分析了来自澳大利亚墨尔本四家HIV诊所的感染HIV的MSM进行的为期2年的肛门癌前瞻性筛查研究基线时采集的肛门拭子。根据年龄和肛交行为对肛门HPV检测进行分层。

结果

281份肛门拭子纳入分析。大多数男性（80%，95%CI 75至84）的任何HPV检测呈阳性；59%（95%CI 53至65）的高危型HPV（hr-HPV）基因型检测呈阳性；31%（95%CI 26至36）的男性HPV 16和/或18检测呈阳性，各年龄组之间无显著差异（p>0.261）。在过去六个月内未报告有接受肛交行为的男性中（22%），未进行肛交行为的男性中53%（95%CI 41至65）检测到hr-HPV，而进行肛交行为的男性中这一比例为60%（95%CI 54至67）（p=0.320）。未进行肛交行为的男性中26%（95%CI 16至38）检测到HPV 16和/或18，而进行肛交行为的男性中这一比例为32%（95%CI 27至39）（p=0.320）。