Prevention and Implementation Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Sci Rep. 2018 May 29;8(1):8241. doi: 10.1038/s41598-018-26589-w.
Data regarding the anogenital distribution of and type-specific concordance for cutaneous β- and γ-HPV types in men who have sex with women is limited and geographically narrow. Knowledge of determinants of anogenital detection of cutaneous HPV types in different regions is needed for better understanding of the natural history and transmission dynamics of HPV, and its potential role in the development of anogenital diseases. Genital and anal canal samples obtained from 554 Russian men were screened for 43 β-HPVs and 29 γ-HPVs, using a multiplex PCR combined with Luminex technology. Both β- and γ-HPVs were more prevalent in the anal (22.8% and 14.1%) samples than in the genital (16.8% and 12.3%) samples. Low overall and type-specific concordance for β-HPVs (3.5% and 1.1%) and γ-HPVs (1.3% and 0.6%) were observed between genital and anal samples. HIV-positive men had higher anal β- (crude OR = 12.2, 95% CI: 5.3-28.1) and γ-HPV (crude OR = 7.2, 95% CI: 3.3-15.4) prevalence than HIV-negative men. Due to the lack of genital samples from the HIV-positive men, no comparison was possible for HIV status in genital samples. The lack of type-specific positive concordance between genital and anal sites for cutaneous β- and γ-HPV types in heterosexual men posits the needs for further studies on transmission routes to discriminate between contamination and true HPV infection. HIV-positive status may favor the anal acquisition or modify the natural history of cutaneous HPV types.
有关与女性发生性行为的男性的肛门生殖器部位皮肤 β 和 γ-HPV 型的分布和特定型别的一致性的数据有限，且地域范围狭窄。为了更好地了解 HPV 的自然史和传播动态及其在肛门生殖器疾病发展中的潜在作用，需要了解不同地区肛门生殖器部位检测到皮肤 HPV 型的决定因素。使用多重 PCR 结合 Luminex 技术，对 554 名俄罗斯男性的生殖器和肛门内样本进行了 43 种 β-HPV 和 29 种 γ-HPV 的筛查。β-HPV（22.8%和 14.1%）和 γ-HPV（14.1%和 12.3%）在肛门样本中的流行率均高于生殖器样本。在生殖器和肛门样本之间，β-HPV（3.5%和 1.1%）和 γ-HPV（1.3%和 0.6%）的总一致性和特定型别一致性均较低。与 HIV 阴性男性相比，HIV 阳性男性的肛门 β-HPV（粗 OR=12.2，95%CI：5.3-28.1）和 γ-HPV（粗 OR=7.2，95%CI：3.3-15.4）的流行率更高。由于 HIV 阳性男性的生殖器样本中缺乏 HIV 状态信息，因此无法对生殖器样本中的 HIV 状态进行比较。在异性恋男性中，生殖器和肛门部位的皮肤 β-和 γ-HPV 型之间缺乏特定型别的阳性一致性，这需要进一步研究传播途径，以区分污染和真正的 HPV 感染。HIV 阳性状态可能有利于肛门获得或改变皮肤 HPV 型的自然史。
