Kim Nan-Ok, Jung Su-Mi, Na Hae-Young, Chung Gyung Tae, Yoo Cheon-Kwon, Seong Won Keun, Hong Sahyun
Division of Enteric Diseases, Center for Infectious Diseases, Korea National Institute of Health, Cheongju, Korea.
Osong Public Health Res Perspect. 2015 Aug;6(4):233-40. doi: 10.1016/j.phrp.2015.07.005. Epub 2015 Aug 7.
The aim of this study was to characterize the pathogens responsible for causing diarrhea according to season, region of isolation, patient age, and sex as well as to provide useful data for the prevention of diarrheal disease.
Stool specimens from 14,886 patients with diarrhea were collected to identify pathogenic bacteria from January 2014 to December 2014 in Korea. A total of 3,526 pathogenic bacteria were isolated and analyzed according to season, region of isolation, and the age and sex of the patient.
The breakdown of the isolated pathogenic bacteria were as follows: Salmonella spp. 476 (13.5%), pathogenic Escherichia coli 777 (22.0%), Vibrio parahaemolyticus 26 (0.74%), Shigella spp. 13 (0.37%), Campylobacter spp. 215 (6.10%), Clostridium perfringens 508 (14.4%), Staphylococcus aureus 1,144 (32.4%), Bacillus cereus 356 (10.1%), Listeria monocytogenes 1 (0.03%), and Yersinia enterocolitica 10 (0.3%). The isolation rate trend showed the highest ratio in the summer season from June to September for most of the pathogenic bacteria except the Gram-positive bacteria. The isolation rate of most of the pathogenic bacteria by patient age showed highest ratio in the 0-19 year age range. For isolation rate by region, 56.2% were isolated from cities and 43.8% were isolated from provinces.
Hygiene education should be addressed for diarrheal disease-susceptible groups, such as those younger than 10 years, aged 10-19 years, and older than 70 years, and monitoring for the pathogens is still required. In addition, an efficient laboratory surveillance system for infection control should be continued.
本研究旨在根据季节、分离地区、患者年龄和性别对引起腹泻的病原体进行特征描述,并为腹泻病的预防提供有用数据。
2014年1月至2014年12月期间,收集了韩国14886例腹泻患者的粪便标本,以鉴定病原菌。共分离出3526株病原菌,并根据季节、分离地区以及患者的年龄和性别进行分析。
分离出的病原菌分类如下:沙门氏菌属476株(13.5%)、致病性大肠杆菌777株(22.0%)、副溶血性弧菌26株(0.74%)、志贺氏菌属13株(0.37%)、弯曲杆菌属215株(6.10%)、产气荚膜梭菌508株(14.4%)、金黄色葡萄球菌1144株(32.4%)、蜡样芽孢杆菌356株(10.1%)、单核细胞增生李斯特菌1株(0.03%)和小肠结肠炎耶尔森菌10株(0.3%)。除革兰氏阳性菌外,大多数病原菌的分离率趋势在6月至9月的夏季最高。大多数病原菌按患者年龄的分离率在0 - 19岁年龄范围内最高。按地区的分离率来看,56.2%分离自城市,43.8%分离自省份。
应针对腹泻病易感人群开展卫生教育,如10岁以下、10 - 19岁和70岁以上人群,并且仍需对病原体进行监测。此外,应继续建立有效的实验室监测系统以控制感染。