空气污染与过敏性疾病。
Air pollution and allergic diseases.
作者信息
Brandt Eric B, Myers Jocelyn M Biagini, Ryan Patrick H, Hershey Gurjit K Khurana
机构信息
aDivision of Asthma Research bDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
出版信息
Curr Opin Pediatr. 2015 Dec;27(6):724-35. doi: 10.1097/MOP.0000000000000286.
PURPOSE OF REVIEW
Exposure to traffic-related air pollutants (TRAPs) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant because increasingly large segments of the population worldwide reside in zones that have high levels of TRAP, including children, as schools are often located in high traffic pollution exposure areas.
RECENT FINDINGS
Recent findings include epidemiologic and mechanistic studies that shed new light on the impact of traffic pollution on allergic diseases and the biology underlying this impact. In addition, new innovative methods to assess and quantify traffic pollution have been developed to assess exposure and identify vulnerable populations and individuals.
SUMMARY
This review will summarize the most recent findings in each of these areas. These findings will have a substantial impact on clinical practice and research by the development of novel methods to quantify exposure and identify at-risk individuals, as well as mechanistic studies that identify new targets for intervention for individuals most adversely affected by TRAP exposure.
综述目的
暴露于交通相关空气污染物（TRAPs）与哮喘的发生、持续和加重有关。这种暴露非常重要，因为全球越来越多的人口居住在TRAP水平较高的区域，包括儿童，因为学校通常位于交通污染暴露水平高的地区。
最新发现
最新发现包括流行病学和机制研究，这些研究为交通污染对过敏性疾病的影响及其背后的生物学机制提供了新的见解。此外，已开发出评估和量化交通污染的新创新方法，以评估暴露情况并识别脆弱人群和个体。
总结
本综述将总结这些领域中的最新发现。这些发现将通过开发量化暴露和识别高危个体的新方法，以及确定受TRAP暴露影响最严重个体的新干预靶点的机制研究，对临床实践和研究产生重大影响。
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