Furer Ariel, Finkelstein Ariel, Halkin Amir, Revivo Miri, Zuzut Meital, Berliner Shlomo, Herz Itzhak, Solodukhin Alex, Ofer Hadas, Keren Gad, Banai Shmuel, Arbel Yaron
a Department of Cardiology , Tel Aviv Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University , Tel Aviv , Israel .
b Department of Internal Medicine "T" , Tel Aviv Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University , Tel Aviv , Israel , and.
Biomarkers. 2015;20(6-7):376-81. doi: 10.3109/1354750X.2015.1096304. Epub 2015 Oct 16.
Preclinical carotid atherosclerosis is associated with future risk of stroke. Data regarding the correlation between carotid atherosclerosis and biomarkers, which might predict the risk for the disease has been inconsistent and conflicting. Red blood cell distribution width (RDW) is also related to adverse clinical outcomes. Studies examining the relationship between RDW and preclinical and clinical carotid atherosclerosis were non-conclusive.
To study the association between RDW and preclinical carotid atherosclerosis in a large heterogeneous cohort.
Patients underwent Doppler ultrasound of the common carotid artery and Carotid Intima Media Thickness (CIMT). Advanced CIMT software analyzed over 100 samples in each exam. Blood samples for RDW were obtained on the same day. Logistic regression was used to evaluate the correlation between RDW and preclinical carotid atherosclerosis.
Five hundred and twenty-two consecutive patients were included, with a mean age of 6.6 ± 11. A cut-off value of 14.1% was used to differentiate between high and low RDW groups. The higher RDW group (RDW above 14.1%) was significantly older and with more cardiovascular risk factors. In a multivariate analysis, in all the patients including those treated by lipid modifying therapies, high RDW was significantly associated with advanced CIMT (OR = 2.35, CI 95% 1.28-4.30, p = 0.006). This association remained significant in subgroups of non-diabetic patients as well as patients not treated by lipid modifying drugs. RDW was also associated with significant carotid artery stenosis (OR = 1.77, CI 95% 1.12-2.82, p = 0.015).
High RDW correlates with increased risk for preclinical and clinical carotid atherosclerosis.
临床前颈动脉粥样硬化与未来中风风险相关。关于颈动脉粥样硬化与生物标志物之间的相关性数据，这些生物标志物可能预测该疾病的风险，一直存在不一致和相互矛盾的情况。红细胞分布宽度（RDW）也与不良临床结局相关。研究RDW与临床前和临床颈动脉粥样硬化之间关系的结果尚无定论。
在一个大型异质性队列中研究RDW与临床前颈动脉粥样硬化之间的关联。
患者接受颈总动脉多普勒超声检查和颈动脉内膜中层厚度（CIMT）测量。先进的CIMT软件在每次检查中分析超过100个样本。同一天采集用于检测RDW的血样。采用逻辑回归评估RDW与临床前颈动脉粥样硬化之间的相关性。
纳入522例连续患者，平均年龄为6.6±11岁。采用14.1%的临界值区分高RDW组和低RDW组。较高RDW组（RDW高于14.1%）年龄显著更大，且有更多心血管危险因素。在多变量分析中，在所有患者中，包括接受调脂治疗的患者，高RDW与CIMT进展显著相关（OR = 2.35，95%CI 1.28 - 4.30，p = 0.006）。这种关联在非糖尿病患者亚组以及未接受调脂药物治疗的患者中也仍然显著。RDW还与显著的颈动脉狭窄相关（OR = 1.77，95%CI 1.12 - 2.82，p = 0.015）。
高RDW与临床前和临床颈动脉粥样硬化风险增加相关。
