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红细胞分布宽度水平与中风风险之间的关联：前瞻性研究的系统评价和荟萃分析

Association between red cell distribution width level and risk of stroke: A systematic review and meta-analysis of prospective studies.

作者信息

Li Bingxian, Liu Shuo, Liu Xiaoqiang, Fang Jingnian, Zhuang Weiduan

机构信息

Neurology Department, First Affiliated Hospital of Shantou University Medical College.

Shantou University Medical College, Shantou, Guangdong, China.

出版信息

Medicine (Baltimore). 2020 Apr;99(16):e19691. doi: 10.1097/MD.0000000000019691.

DOI:10.1097/MD.0000000000019691
PMID:32311945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7220702/
Abstract

BACKGROUND

Red cell distribution width level may have relations with the incidence and prognosis of cerebrovascular diseases. Recent researches have reported that red cell distribution width level was linked to the occurrence of stroke. However, the predicted effect of red cell distribution width in stroke is still disputed. We sought to assess the relationship between red cell distribution width and risk of stroke in this meta-analysis.

METHODS

Relevant studies were picked out from the databases of Embase, PubMed, and Cochrane Library. Hazard ratio with 95% confidence interval was chosen to analyze each trial, which was extracted from results of the highest and lowest red cell distribution width group. Funnel plots, Begg and Egger test were used to assess publication bias in the meta-analysis. Stata(12.0) was utilized to perform statistic analysis in the process.

RESULTS

A total of 6 studies with 5783 patients were included in this meta-analysis. The results showed that red cell distribution width level in patients with stroke was significantly higher than it in those without stroke (HR = 1.34, 95%CI:1.23-1.47, P < .001), in particular ischemic stroke(HR = 1.34,95% confidence interval:1.1-1.54, P < .001). There was no evidence of heterogeneity across the studies (P = .355, I = 5.53%).

CONCLUSIONS

The higher red cell distribution width level was associated with an increased risk of stroke, especially ischemic infarction.

摘要

背景

红细胞分布宽度水平可能与脑血管疾病的发病率及预后相关。近期研究报道红细胞分布宽度水平与中风的发生有关。然而，红细胞分布宽度在中风中的预测作用仍存在争议。我们试图在这项荟萃分析中评估红细胞分布宽度与中风风险之间的关系。

方法

从Embase、PubMed和Cochrane图书馆数据库中挑选相关研究。选择具有95%置信区间的风险比来分析每个试验，该风险比从红细胞分布宽度最高和最低组的结果中提取。采用漏斗图、Begg检验和Egger检验来评估荟萃分析中的发表偏倚。在此过程中使用Stata（12.0）进行统计分析。

结果

本荟萃分析共纳入6项研究，涉及5783例患者。结果显示，中风患者的红细胞分布宽度水平显著高于非中风患者（风险比=1.34，95%置信区间：1.23 - 1.47，P<0.001），尤其是缺血性中风（风险比=1.34，95%置信区间：1.1 - 1.54，P<0.001）。各研究之间没有异质性证据（P = 0.355，I² = 5.53%）。

结论

较高的红细胞分布宽度水平与中风风险增加相关，尤其是缺血性梗死。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/bdf7dc3c39b5/medi-99-e19691-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/ea533994c60f/medi-99-e19691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/d204eb8ef257/medi-99-e19691-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/89474d05061d/medi-99-e19691-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/58e28861529a/medi-99-e19691-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/bdf7dc3c39b5/medi-99-e19691-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/ea533994c60f/medi-99-e19691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/d204eb8ef257/medi-99-e19691-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/89474d05061d/medi-99-e19691-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/58e28861529a/medi-99-e19691-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ee/7220702/bdf7dc3c39b5/medi-99-e19691-g006.jpg

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