Ren Dongdong, Wang Juan, Li Hua, Li Yanyan, Li Zhanzhan
Emergency Department, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, 450002, People's Republic of China.
Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, 450002, People's Republic of China.
BMC Cardiovasc Disord. 2017 Jan 28;17(1):44. doi: 10.1186/s12872-017-0481-x.
To evaluate the relationship between red blood cell distribution width (RDW) and carotid intima-media thickness (CIMT) in metabolic syndrome (MetS) patients.
In this study, we analyzed 803 patients with MetS who underwent carotid ultrasonography examination at Henan Province Hospital of Traditional Chinese Medicine from October 2014 to September 2015. Demographic data were collected using a questionnaire. An automatic biochemistry analyzer measured RDW. Pearson correlation coefficient, multivariate linear and logistic regression was used to evaluate the correlation between RDW and CIMT.
Compared with control group, case group had higher RDW level (P < 0.001) and CIMT (P < 0.001). CIMT was positively related to RDW (r = 0.436, P < 0.001). Logistic regression indicated that RDW was a predictor of CIMT ≥ 1 mm. Compared with the first quartile, people with third and fourth quartile level gave obvious higher risk of carotid artery atherosclerotic trend (OR = 1.41, 95% CI:1.01-197; OR = 2.10, 95% CI: 1.30-3.40). Using a cutoff point of 13.9%, RDW predicts elevated CIMT with a sensitivity of 62.1% and a specificity of 70.3%.
High RDW is related to the increased CIMT in MetS patients, which highlights the role of RDW in the progression of elevated CIMT in MetS patients.
评估代谢综合征（MetS）患者中红细胞分布宽度（RDW）与颈动脉内膜中层厚度（CIMT）之间的关系。
在本研究中，我们分析了2014年10月至2015年9月在河南省中医院接受颈动脉超声检查的803例MetS患者。使用问卷收集人口统计学数据。采用自动生化分析仪测量RDW。使用Pearson相关系数、多元线性和逻辑回归评估RDW与CIMT之间的相关性。
与对照组相比，病例组的RDW水平（P < 0.001）和CIMT（P < 0.001）更高。CIMT与RDW呈正相关（r = 0.436，P < 0.001）。逻辑回归表明，RDW是CIMT≥1 mm的预测因子。与第一四分位数相比，处于第三和第四四分位数水平的人颈动脉粥样硬化趋势风险明显更高（OR = 1.41，95%CI：1.01 - 1.97；OR = 2.10，95%CI：1.30 - 3.40）。以13.9%为截断点，RDW预测CIMT升高的灵敏度为62.1%，特异度为70.3%。
高RDW与MetS患者CIMT增加有关，这突出了RDW在MetS患者CIMT升高进展中的作用。
