Zhou Jian, Li Chuang-Jun, Yang Jing-Zhi, Ma Jie, Wu Lian-Qiu, Wang Wen-Jie, Zhang Dong-Ming
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China; Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Phytochemistry. 2016 Jan;121:58-64. doi: 10.1016/j.phytochem.2015.10.002. Epub 2015 Oct 21.
Four phenylpropanoid glucosides (1-4) and five lignan glycosides (5-9) were isolated from the aerial parts of Lespedeza cuneata, together with three known lignan glycosides (10-12). Their structures were elucidated on the basis of spectroscopic analyses, and the absolute configurations of compounds 5-9 were determined from the CD spectra. In addition, the compounds were tested for their ability to activate the transcription effect on xbp1 promoter. Compounds 4, 5, 7, 9, 10, and 12 could activate the transcription of xbp1 to varying degrees, with EC50 values ranging from 0.18 to 0.64 μM.
从截叶铁扫帚地上部分分离得到4个苯丙素苷（1 - 4）和5个木脂素苷（5 - 9），以及3个已知木脂素苷（10 - 12）。通过光谱分析阐明了它们的结构，并根据圆二色光谱确定了化合物5 - 9的绝对构型。此外，测试了这些化合物激活xbp1启动子转录效应的能力。化合物4、5、7、9、10和12能够不同程度地激活xbp1的转录，其半数有效浓度（EC50）值在0.18至0.64 μM之间。
