来自日本蓟的细胞毒性苯丙素苷。
Cytotoxic phenylpropanoid glycosides from Cirsium japonicum.
作者信息
Shang Dong-Li, Ma Qin-Ge, Wei Rong-Rui
机构信息
a Department of Cardiology , Nanyang the First People's Hospital , Nanyang 473002 , China.
b College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang 473061 , China.
出版信息
J Asian Nat Prod Res. 2016 Dec;18(12):1122-1130. doi: 10.1080/10286020.2016.1194831. Epub 2016 Jun 16.
Three new phenylpropanoid glycosides 1-3, along with nine known phenylpropanoid glycosides 4-12, were isolated from the aerial parts of Cirsium japonicum. The structures of isolated compounds were elucidated by chemical and spectroscopic methods. Compounds 1, 3, 6, 8, and 11 showed moderate cytotoxicities against MCF-7, U87, HCT116, and A549 cell lines with IC values in the range of 1.35-11.32 μM. The known compounds 4-12 were obtained from this plant for the first time.
从大蓟的地上部分分离出三种新的苯丙素苷1 - 3，以及九种已知的苯丙素苷4 - 12。通过化学和光谱方法阐明了分离出的化合物的结构。化合物1、3、6、8和11对MCF - 7、U87、HCT116和A549细胞系表现出中等细胞毒性，IC值在1.35 - 11.32μM范围内。已知化合物4 - 12首次从该植物中获得。
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