Chihara J, Nakajima S
Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
Allergy Proc. 1989 Jan-Feb;10(1):27-32. doi: 10.2500/108854189778968515.
We have previously reported pulmonary eosinophils in eosinophilic pneumonia (PIE syndrome) showed two characteristics: hypodensity and nuclear hypersegmentation. Our present working hypothesis is that the eosinophil chemotactic factor and certain lymphokines may be involved in the induction of these characteristic features. Therefore, we examined whether these stimuli can induce two characteristics in vitro. Results were as follows. 1) Chemoattracts (ECF-A, histamine and PAF) can induce both nuclear hypersegmentation and hypodense eosinophils. 2) Hypodense eosinophils can be induced earlier than induction of hypersegmented nuclei (hypodense eosinophils within three hours, hypersegmented nuclei: 12 hrs). 3) Furthermore, lymphokines can not induce hypodense eosinophil. 4) However, PHA-lymphocyte culture medium (PHALCM), gamma-IFN and IL-3 + GM-CSF can induce hypersegmented nuclei but IL-2 has no effect on nuclear segmentation of eosinophils.
我们之前报道过，嗜酸性粒细胞性肺炎（PIE综合征）中的肺嗜酸性粒细胞表现出两个特征：低密度和核多分叶。我们目前的工作假设是，嗜酸性粒细胞趋化因子和某些淋巴因子可能参与了这些特征的诱导。因此，我们研究了这些刺激物在体外是否能诱导出这两个特征。结果如下：1）趋化因子（嗜酸性粒细胞趋化因子A、组胺和血小板活化因子）能诱导核多分叶和低密度嗜酸性粒细胞。2）低密度嗜酸性粒细胞的诱导早于多分叶核的诱导（3小时内出现低密度嗜酸性粒细胞，多分叶核：12小时）。3）此外，淋巴因子不能诱导出低密度嗜酸性粒细胞。4）然而，PHA淋巴细胞培养基（PHALCM）、γ干扰素和IL-3 + GM-CSF能诱导多分叶核，但IL-2对嗜酸性粒细胞的核分叶没有影响。
