Humphreys S, Spencer J D, Tighe J R, Cumming R R
Department of Morbid Anatomy, King's College Hospital, London, England.
J Bone Joint Surg Br. 1989 Mar;71(2):205-8. doi: 10.1302/0301-620X.71B2.2647752.
The occurrence of osteonecrosis following renal transplantation is well recognised but its pathogenesis remains unknown. We have quantified the number of empty osteocytic lacunae in the subchondral bone of femoral heads from a control group of patients, and compared these with femoral heads from a group of renal transplant recipients without evidence of overt osteonecrosis. There is a significant increase in empty osteocytic lacunae in renal transplant patients. We conclude that loss of osteocytes precedes other manifestations of osteonecrosis.
肾移植后发生骨坏死已得到充分认识，但其发病机制仍不清楚。我们对一组对照组患者股骨头软骨下骨中骨细胞空陷窝的数量进行了量化，并将其与一组无明显骨坏死证据的肾移植受者的股骨头进行了比较。肾移植患者的骨细胞空陷窝数量显著增加。我们得出结论，骨细胞的丢失先于骨坏死的其他表现。
