Ranjbar-Mohammadi Marziyeh, Zamani M, Prabhakaran M P, Bahrami S Hajir, Ramakrishna S
Textile Engineering Group, Department of Engineering, University of Bonab, Bonab, Iran.
Mechanical Engineering Department, National University of Singapore, Singapore; Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore.
Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:521-31. doi: 10.1016/j.msec.2015.08.066. Epub 2015 Sep 3.
Controlled drug release is a process in which a predetermined amount of drug is released for longer period of time, ranging from days to months, in a controlled manner. In this study, novel drug delivery devices were fabricated via blend electrospinning and coaxial electrospinning using poly lactic glycolic acid (PLGA), gum tragacanth (GT) and tetracycline hydrochloride (TCH) as a hydrophilic model drug in different compositions and their performance as a drug carrier scaffold was evaluated. Scanning electron microscopy (SEM) results showed that fabricated PLGA, blend PLGA/GT and core shell PLGA/GT nanofibers had a smooth and bead-less morphology with the diameter ranging from 180 to 460 nm. Drug release studies showed that both the fraction of GT within blend nanofibers and the core-shell structure can effectively control TCH release rate from the nanofibrous membranes. By incorporation of TCH into core-shell nanofibers, drug release was sustained for 75 days with only 19% of burst release within the first 2h. The prolonged drug release, together with proven biocompatibility, antibacterial and mechanical properties of drug loaded core shell nanofibers make them a promising candidate to be used as drug delivery system for periodontal diseases.
控释药物是一种将预定量药物以可控方式在较长时间内（从数天到数月）释放的过程。在本研究中，使用聚乳酸乙醇酸（PLGA）、刺梧桐树胶（GT）和盐酸四环素（TCH）作为亲水性模型药物，通过共混静电纺丝和同轴静电纺丝制备了新型药物递送装置，其组成各不相同，并评估了它们作为药物载体支架的性能。扫描电子显微镜（SEM）结果表明，制备的PLGA、共混PLGA/GT和核壳PLGA/GT纳米纤维具有光滑无珠的形态，直径范围为180至460nm。药物释放研究表明，共混纳米纤维中GT的比例和核壳结构均可有效控制纳米纤维膜中TCH的释放速率。通过将TCH掺入核壳纳米纤维中，药物释放持续75天，在前2小时内仅19%的药物出现突释。药物的长效释放，以及负载药物的核壳纳米纤维已被证实的生物相容性、抗菌和机械性能，使其成为用于牙周疾病药物递送系统的有前途的候选材料。
