Golde D W, Burgaleta C, Sparkes R S, Cline M J
Blood. 1977 Mar;49(3):367-70.
Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed. All cell metaphases examined contained the Ph1 chromosome at a time when more than 80% of these metaphases were in identifiable macrophages. We conclude that the mononuclear phagocyte cell line contains the abnormal chromosome in Ph1-positive chronic myelocytic leukemia.
对三名处于疾病自然史不同阶段的慢性粒细胞白血病患者进行了研究。在有利于巨噬细胞增殖的条件下培养他们的骨髓细胞，并进行了平行的细胞遗传学和细胞化学研究。在超过80%的这些中期细胞可鉴定为巨噬细胞时，所有检查的细胞中期都含有Ph1染色体。我们得出结论，在Ph1阳性慢性粒细胞白血病中，单核吞噬细胞系含有异常染色体。
