Wang Hua-nan, Zhou Wei, Mao Bing
Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Jul;46(4):581-5.
To study the syndrome of traditional Chinese medicine (TCM) and relevant indexes of conventional Western medicine for patients with chronic obstructive pulmonary disease (COPD) at stable phase, and further explore the trend of change of the deficiency syndrome of TCM, and the correlation of each syndrome with the BODE index (body mass index, airflow obstruction, dyspnea, and exercise capacity index) and quality of life.
300 cases with COPD which were in line with the standard were differentiated to 5 groups (60 cases for each group) by the symptoms. which were Lung Qi deficiency (Group A), Lung and Spleen Qi deficiency (Group B), Lung and Kidney Qi deficiency (Group C), Lung, Spleen and Kidney Qi deficiency (Group D), and deficiency of both Qi and Yin (Group E). Some basic details about the patients were recorded, such as body mass and height. Also BODE index and COPD assessment test were conducted. And then the differences of the indexes among groups, the relationship between the BODE index and the COPD assessment test (CAT) score were analyzed.
Comparison in 5 groups, the body mass index (BMD and forced expiratory volume in 1 s to forced vital capacity ratio (FEV1%) of Group A was the highest, the 6-min walk distance (6MWD) of Group A was the longest, but the degree of dyspnea, BODE index and CAT score of patients in Group A were the lowest (P < 0.05) No statistical significance of above index and score between Group D and E was observed (P > 0.05). In Group D and E, the BMI and FEV1% was the lowest, 6MWD was the shortest, and the degree of dyspnea of patients was the highest (P < 0.05). A positive correlation between BODE index and CAT score observed (r = 0.883, P < 0.05).
With the progress of COPD, disease from single viscera gradually accumulated to multiple viscera, from Group A --> Group B/Group C --> Group D, with the gradually increasing of BODE index and CAT score.
研究慢性阻塞性肺疾病（COPD）稳定期患者的中医证候及相关西医指标，进一步探讨中医虚证的变化趋势，以及各证候与BODE指数（体重指数、气流阻塞、呼吸困难和运动能力指数）和生活质量的相关性。
将符合标准的300例COPD患者按症状分为5组（每组60例），分别为肺气虚证（A组）、肺脾气虚证（B组）、肺肾气虚证（C组）、肺脾肾气亏虚证（D组）、气阴两虚证（E组）。记录患者的一些基本情况，如体重和身高。同时进行BODE指数和COPD评估测试。然后分析各组指标的差异、BODE指数与COPD评估测试（CAT）评分之间的关系。
5组比较，A组的体重指数（BMI）和第1秒用力呼气容积占用力肺活量比值（FEV1%）最高，A组的6分钟步行距离（6MWD）最长，但A组患者的呼吸困难程度、BODE指数和CAT评分最低（P<0.05）。D组与E组上述指标及评分比较差异无统计学意义（P>0.05）。D组和E组的BMI和FEV1%最低，6MWD最短，患者呼吸困难程度最高（P<0.05）。BODE指数与CAT评分呈正相关（r = 0.883，P<0.05）。
随着COPD病情进展，病变从单一脏腑逐渐累及多个脏腑，从A组→B组/C组→D组，BODE指数和CAT评分逐渐升高。
