Cesari Matteo, Vellas Bruno
Nestle Nutr Inst Workshop Ser. 2015;83:93-8. doi: 10.1159/000382091. Epub 2015 Oct 20.
Frailty is a geriatric syndrome characterized by reduced homeostatic reserves, exposing the organism to extreme vulnerability to endogenous and exogenous stressors. Since disability is considered as an almost irreversible condition at advanced age, frailty has been indicated as a promising target for specific interventions in order to prevent disability. From a theoretical viewpoint, the concept of frailty has been well established, but its operationalization is still subject to controversy. This impediment leads to the postponement of the integration of frailty in the clinical setting. In the present article, we discuss the main issues regarding the frailty syndrome in the clinical setting, describe possible solutions (especially on the basis of our experience derived from the frailty clinic we have set up in Toulouse, France), and present the most relevant research perspectives in the field.
衰弱是一种老年综合征，其特征是体内稳态储备减少，使机体极易受到内源性和外源性应激源的影响。由于残疾在高龄时被认为几乎是不可逆的状况，衰弱已被视为特定干预措施的一个有前景的目标，以预防残疾。从理论角度来看，衰弱的概念已经确立，但对其的操作化仍存在争议。这一障碍导致衰弱在临床环境中的整合被推迟。在本文中，我们讨论了临床环境中与衰弱综合征相关的主要问题，描述了可能的解决方案（特别是基于我们在法国图卢兹设立的衰弱诊所的经验），并展示了该领域最相关的研究前景。
