瘢痕疙瘩中微小RNA的失调：临床干预的契机？
microRNA deregulation in keloids: an opportunity for clinical intervention?
作者信息
Yu Xin, Li Zheng, Chan Matthew T V, Wu William K K
机构信息
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
出版信息
Cell Prolif. 2015 Dec;48(6):626-30. doi: 10.1111/cpr.12225. Epub 2015 Oct 21.
Abstract
Keloids are defined as benign dermal scars invading adjacent healthy tissue, characterized by aberrant fibroblast dynamics and overproduction of extracellular matrix. However, the aetiology and molecular mechanism of keloid production remain poorly understood. Recent discoveries have shed new light on the involvement of a class of non-coding RNAs known as microRNAs (miRNA), in keloid formation. A number of miRNAs have differential expression in keloid tissues and keloid-derived fibroblasts. These miRNAs have been characterized as novel regulators of cellular processes pertinent to wound healing, including extracellular matrix deposition and fibroblast proliferation. Delineating the functional significance of miRNA deregulation may help us better understand pathogenesis of keloids, and promote development of miRNA-directed therapeutics against this condition.
摘要
瘢痕疙瘩被定义为侵入相邻健康组织的良性皮肤瘢痕，其特征是成纤维细胞动力学异常和细胞外基质过度产生。然而，瘢痕疙瘩形成的病因和分子机制仍知之甚少。最近的发现为一类称为微小RNA（miRNA）的非编码RNA参与瘢痕疙瘩形成提供了新线索。许多miRNA在瘢痕疙瘩组织和瘢痕疙瘩来源的成纤维细胞中存在差异表达。这些miRNA已被表征为与伤口愈合相关的细胞过程的新型调节因子，包括细胞外基质沉积和成纤维细胞增殖。阐明miRNA失调的功能意义可能有助于我们更好地理解瘢痕疙瘩的发病机制，并促进针对这种疾病的miRNA导向疗法的发展。
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