Jiang Xiong-ying, Gu Yang-kui, Huang Jin-hua, Gao Fei, Zou Ru-hai, Zhang Tian-qi
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China.
Department of Minimally Invasive Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Cardiovasc Intervent Radiol. 2016 Apr;39(4):600-5. doi: 10.1007/s00270-015-1218-9. Epub 2015 Oct 20.
To compare temperature, energy, and coagulation between hydrochloric acid-infused radiofrequency ablation (HAIRFA) and normal saline-infused radiofrequency ablation (NSIRFA) in ex vivo porcine liver model.
30 fresh porcine livers were excised in 60 lesions, 30 with HAIRFA and the other 30 with NSIRFA. Both modalities used monopolar perfusion electrode connected to a RF generator set at 103 °C and 30 W. In each group, ablation time was set at 10, 20, or 30 min (10 lesions from each group at each time). We compared tissue temperatures (at 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 cm away from the electrode tip), average power, deposited energy, deposited energy per coagulation volume (DEV), coagulation diameters, coagulative volume, and spherical ratio between the two groups.
Temperature-time curves showed that HAIRFA provided progressively greater heating than that of NSIRFA. At 30 min, mean average power, deposited energy, coagulation volumes (113.67 vs. 12.28 cm(3)) and diameters, and increasing in tissue temperature were much greater with HAIRFA (P < 0.001 for all), except DEV was lower (456 vs. 1396 J/cm(3), P < 0.001). The spherical ratio was closer to 1 with HAIRFA (1.23 vs. 1.46). Coagulation diameters, volume, and average power of HAIRFA increased significantly with longer ablation times. While with NSIRFA, these characteristics were stable till later 20 min, except the power decreased with longer ablation times.
HAIRFA creates much larger and more spherical lesions by increasing overall energy deposition, modulating thermal conductivity, and transferring heat during ablation.
在离体猪肝脏模型中比较注入盐酸的射频消融术（HAIRFA）和注入生理盐水的射频消融术（NSIRFA）之间的温度、能量及凝固情况。
切除30个新鲜猪肝脏，制造60个病灶，其中30个采用HAIRFA，另外30个采用NSIRFA。两种方式均使用连接到设定为103℃和30W的射频发生器的单极灌注电极。每组中，消融时间设定为10、20或30分钟（每组每次10个病灶）。我们比较了两组之间的组织温度（距电极尖端0.5、1.0、1.5、2.0、2.5和3.0厘米处）、平均功率、沉积能量、每凝固体积的沉积能量（DEV）、凝固直径、凝固体积和球形比。
温度-时间曲线显示，HAIRFA比NSIRFA产生的加热效果逐渐更强。30分钟时，HAIRFA的平均平均功率、沉积能量、凝固体积（113.67对12.28立方厘米）和直径以及组织温度的升高都显著更高（所有P<0.001），但DEV较低（456对1396焦/立方厘米，P<0.001）。HAIRFA的球形比更接近1（1.23对1.46）。HAIRFA的凝固直径、体积和平均功率随消融时间延长显著增加。而对于NSIRFA，这些特征在20分钟之前保持稳定，除了功率随消融时间延长而降低。
HAIRFA通过增加整体能量沉积、调节热导率以及在消融过程中传递热量，产生更大且更接近球形的病灶。
